摘要
齐墩果酸（oleanolic acid,OA）又名庆四素（图1）,系五环三萜类化合物,以游离或结合成苷的形式广泛存在于白花蛇舌草、山楂、丁香、大枣、女贞子、枇杷叶、橡木和夏枯草等植物中。
A LC-MS method was established for the determination of the protein binding rates of oleanolic acid in human plasma and serum albumin.The equilibrium dialysis combined with LC-MS to determine the total concentration in plasma and free drug concentration of oleanolic acid was carried out.The human plasma protein binding rates of oleanolic acid at three concentrations were 79.6%,81.9% and 63.3%,respectively.The human serum albumin protein binding rates of oleanolic acid at three concentrations were 53.5%,56.6% and 47.7%,respectively.The method is shown to be simple,accurate,sensitive and specific for the determination of biological samples.The protein binding rates in human plasma and serum albumin were of high strength.
出处
《药学学报》
CAS
CSCD
北大核心
2011年第2期243-246,共4页
Acta Pharmaceutica Sinica
