摘要
目的探讨1H-MRS鉴别多系统萎缩(MSA)与帕金森病(PD)的价值。方法收集临床确诊的18例MSA患者(MSA组)和17例PD患者(PD组),以其中常规MRI表现正常的MSA患者为MSA常规MRI表现正常组,另选17名年龄、性别匹配的正常人为对照组,均接受常规MRI和1H-MRS检查。1H-MRS感兴趣区为两侧壳核、额叶白质及脑桥,体积为1.0 cm×1.0 cm×1.0 cm。结果 MSA组脑桥和壳核的NAA/Cr较PD组和对照组均显著降低(P均<0.05),MSA组脑桥的Cho/Cr较PD组和对照组均显著降低(P均<0.05);PD组壳核的NAA/Cr较对照组显著降低(P<0.05);额叶白质区的Cho/Cr和NAA/Cr三组相比差异均无统计学意义。MSA常规MRI表现正常组脑桥的NAA/Cr较PD组和对照组均显著降低(P均<0.05)。MSA常规MRI表现正常组壳核的NAA/Cr与对照组相比显著降低(P<0.05)。结论 1H-MRS对这两种疾病鉴别诊断有一定帮助,尤其是脑桥的NAA/Cr鉴别诊断常规MRI表现正常的MSA患者与PD患者有一定价值。
Objective To explore the value of 1H-MRS in differential diagnosis between multiple system atrophy（MSA） and Parkinson disease（PD）.Methods MRI features of 18 patients with MSA and 17 patients with PD were retrospectively analyzed.And 17 sex and age matched healthy subjects were regarded as control.1H-MRS sequences were performed,and the regions of interest（ROI） included the bilateral putamen and pons with a 1.0 cm3 spatial resolution.Results The peak area ratios of NAA/Cr significantly decreased in patients with MSA compared to patients with PD and the controls in the pons and bilateral putamen（all P0.05）.The peak area ratios of Cho/Cr also significantly decreased in patients with MSA compared to patients with PD and the controls in the pons.The peak area ratios of NAA/Cr significantly decreased（P0.05） in patients with PD compared to the controls in the bilateral putamen.The peak area ratios of NAA/Cr and Cho/Cr in bilateral cerebral white matter were not statistically different among patients with MSA,patients with PD and the controls.The peak area ratios of NAA/Cr in the pons significantly decreased in patients with MSA who had normal MRI results compared to patients with PD and the controls（P0.05）.The peak area ratios of NAA/Cr in bilateral putamen significantly decreased in patients with MSA who had normal MRI results compared to the controls（P0.05）.Conclusion 1H-MRS is helpful to the differential diagnosis between MSA and PD.The ratio of NAA/Cr in the pons has certain value for early differential diagnosis of patients with the MSA and PD.
出处
《中国医学影像技术》
CSCD
北大核心
2011年第2期273-276,共4页
Chinese Journal of Medical Imaging Technology
关键词
多系统萎缩
帕金森病
磁共振波谱
Multiple system atrophy
Parkinson disease
Magnetic resonance spectroscopy
