摘要
目的:探讨MRI体积测量在帕金森病形态学改变上的意义,及在早期诊断上的作用。材料和方法:利用3T磁共振成像系统对帕金森病病人和正常对照组者分别进行3D-FSPGR的T1WI序列,FSE的PDWI/T2WI序列的扫描。其中早期PD病人16例,晚期PD病人8例,正常对照组8例。通过三维容积重建的方法测量出全脑体积、双侧尾状核、壳核、苍白球,以及黑质的体积,并对体积值进行标化处理。比较分析早期PD组,晚期PD组,对照组三组之间的差异。结果:PD病人的全脑体积和正常人无差异(P>0.05),早期和晚期帕金森病的壳核体积均小于正常人(P<0.05),减小程度分别为12.5%和26.5%。晚期PD的壳核体积较早期PD减小了16.0%(P=0.002)。晚期PD组苍白球体积较对照组下降19.2%(P=0.023)。尾状核、黑质体积在对照组、早晚期PD组中无显著差别(P>0.05)。结论:早和晚期PD的壳核,晚期PD的苍白球形态上已出现萎缩,尾状核,黑质没有明显萎缩。壳核的体积测量可能为早期PD的诊断提供一种有效的方法。
Purpose： To evaluate the ability of MRI - based volumetry to detect the changes of morphology in Parkinson＇s disease（PD）, and to explore the value of volumetric measurement for the diagnosis of PD in early stage. Materials and Methods： 16 patients with early stage PD, 8 patients with advanced PD, and 8 normal controls had been scanned with 3D - FSPGR and FSE sequences by 3T MR. The volumes of caudate, putamen, globus pallidus, substatia nigra of both sides, and total brain were measured on 3 - dimensional reconstructed imagings. Results：. Patients with PD had no significantly reduced total brain volume （P 〉 0.05）. The putamen volume was significantly diminished in both early stage PD and advanced PD compared with that in controls （P〈 0.05）, and the percentage of atrophy was 12.5% and 26.5%, respectively. The reduced volume of globns pallidns was detected only in advanced PD（P 〈 0.05）. There were no significant differences in total brain, caudate, or substatia nigra between early stage PD , advanced PD, and controls. Conclusion： MRI - based volumetry can provide more useful information about PD in vivo. The volumetric measurement of putamen could possibly be a useful method for diagnosis of PD in early stage.
出处
《中国医学计算机成像杂志》
CSCD
2006年第1期6-10,共5页
Chinese Computed Medical Imaging
关键词
帕金森病
磁共振成像
体积测量
Parkinson disease Magnetic resonance imaging Volumetric measurement
