摘要
目的探讨Glil和β—catenin在tH,细胞肺癌组织中细胞核表达与临床病理学特征的关系及其相互关系。方法采用免疫组织化学SP法，检测58例非小细胞肺癌患者及15例癌旁组织中β-catenin和Glil的表达。结果15例癌旁组织中，Glil和β—catenin在正常支气管上皮细胞和腺细胞膜表达，极少胞质和胞核内表达，癌组织细胞核表达明显增高；Glil细胞核表达与分化程度（P〈0．05）、以及TNM分期（P〈0．05）差异有统计学意义，而与淋巴结转移（P〉0．05）无关；β—catenin核表达与分化程度、淋巴结转移以及TNM分期差异均有统计学意义（P〈0．05）；Glil和β-catenin在非小细胞肺癌细胞核表达呈负相关（r=-0．386，P=0．03）。结论Glil和β—catenin细胞核表达上调可能与非小细胞肺癌的发生、发展密切相关。
Objective To investigate the expressions of Glil and β - eatenln protein in the tissues of non -small cell lung cancer（NSCLC） ,and the relationship between the expressions and clinical pathological features. Methods The protein expressions of Glil and β - catenin were determined by immunohistochemical SP method in lung carcinoma tissues （n = 58 ）and adjacent normal lung tissues （n = 15 ）. Results Glil and β - catenin were positively expressed on the cytomembrane of the epithelial cells and adenocytes of normal lung tissues,less expressed in the cytoplasm and nucleus. On the contrary, their expressions were higher in the nuclei in the tumor tissues than in the normal tissue. The nuclear expression rate of Glil protein in lung carcinoma was closely related to the histological differentiation and TNM staging （ P 〈 0.05 ）. The nuclear expression of β - catenin was positively associated with histological differentiation,TNM staging（P 〈0.05） ,and especially,lymph node metastasis（P 〈0.01 ）. Conclusion The up- regulation of expression of Glil and β - catenin in the nuclei of NSCLS cells are closely related with the carcinogenesis and progression of NSCLC.
出处
《临床外科杂志》
2010年第6期399-401,I0001,共4页
Journal of Clinical Surgery
