期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

紫杉醇生物合成综述 被引量：1

REVIEW ON TAXOL BIOSYNTHESIS
在线阅读 下载PDF
导出
摘要 本文对近年来紫杉醉生物合成及生物合成途径中关键酶的研究进展进行了评述。日前紫杉醇的生物合成途径已初见端倪，其生物合成途径中环化酶的基因已经克隆成功。在分子及基因水平上生产紫杉醇的曙光开始出现。 Recent advances on the biosynthesis of taxol and related key enzymes were reviewed. UP to the date, taxolbiosynthetic pathway has been studied in more details, and the gene of taxadiene synthase, a GGPP cyclase catalyzes thefirst committed step of taxol biosynthesis has been cloned successfully. Those progresses indicated that the mass productionof taxol on molecular and gene will level be achieved in the future.
作者 沈月毛 甘烦远 张宏杰 郝小江
机构地区 中国科学院昆明植物研究所
出处 《化学研究与应用》 CAS CSCD 1999年第5期460-464,共5页 Chemical Research and Application
基金 中国科学院"九.五"基础研究生物科学技术特别支持课题!SH-11
关键词 紫杉醇 生物合成 关键酶 环化醇 taxol biosynthesis key enzyme
分类号 TQ464.1 [化学工程—制药化工]
  • 相关文献

参考文献5

  • 1孙雷心.－[J].生物技术通报,1997,(1):32-32.
  • 2梅兴国 胡道伟 等.－[J].国外医药：植物学分册,1996,11:247-247.
  • 3孙雷心，生物技术通报，1997年，1期，32页
  • 4Lin XY，Biochemistry，1996年，35卷，2968页
  • 5梅兴国，国外医药.植物药分册，1996年，11卷，247页

同被引文献19

  • 1Jennewein S, Rithner CD, Williams RM, Croteau RB. Taxol biosynthesis: Taxane 13alpha - hydroxylase is a cytochrome P450-dependent monooxygenase. Proc Natl Acad Sci, USA,2001, 98:13595-13600.
  • 2Hefner J, Croteau R. Cloning and functional expression of a cDNA encoding geranylgeranyl-diphosphate synthase from Taxus Canadensis and assessment of the role of this prenyltransferase in cells induced for Taxol production. Arch Biochem Biophys, 1998, 360 (1):62-74.
  • 3Wildung MR, Croteau R. A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis. J Biol Chem, 1996, 271:9201-9204.
  • 4Hefner J, Rubenstein SM, Ketchum REB, Gibson DM,Willams RM, Croteau R. Cytochrome P450-catalyzed hydroxylation of taxa-4 (5) , 11 (12) 2díene to taxa-4 (20) ,11 (12) -dien-5α-ol: the first oxygenation step in taxol biosynthesis. Chem Biol, 1996, 3:479-489.
  • 5Schoendorf A, Rithner CD, Williams RM, Croteau RB.Molecular cloning of a cytochrome P450 taxane 10betahydroxylase cDNA from Taxus and functional expression in yeast. Proc Natl Acad Sci, USA, 2001, 98:1501-1506.
  • 6Walker K, Schoendorf A, Croteau R. Molecular cloning of a taxa-4 (20), 11 (12)-dien-5α-ol-O-Acetyl transferase cDNA from Taxus and functional expression in Eschericha coli.Arch Biochem Biophys, 2000a, 374:371-380.
  • 7Walker K, Croteau R. Taxol biosynthesis: Molecular cloning of a benzoyl- CoA: taxane 2alpha -O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli.Proc Natl Acad Sci, USA, 2000b, 97: 13591-13596.
  • 8Walker K, Croteau R. Molecular cloning of a 10-deacetylbaccatin Ⅲ-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Proc Natl Acad Sci, USA, 2000c, 97:583-587.
  • 9Walker K, Fujisaki S, Long R, Croteau R. Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in Taxol biosynthesis. Proc Natl Acad Sci, USA, 2002a, 99:12715-12720.
  • 10Walker K, Long R, Croteau R. The final acylation step in Taxol biosynthesis: Cloning of the taxoid C13-side-chain Nbenzoyltransferase from Taxus. Proc Natl Acad Sci, USA,2002b, 99:9166-9171.

引证文献1

二级引证文献5

化学研究与应用
1999年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部