摘要
过氧化物酶增殖物激活受体（peroxisome proliferator activated receptors,PPAR）是一类配体依赖性的核转录因子,调控多种基因表达.最近的研究显示PPAR配体能在炎症反应中作用于多种细胞和多个分子位点,通过抑制细胞因子、趋化因子、黏附分子等的基因表达而发挥抗炎作用.细胞与分子水平就PPAR及其配体的抗炎机制作一综述.
Peroxisome proliferator-activated receptor （PPAR） is a class of ligand-dependent nuclear transcription factor,regulating a variety of gene expression. Recent studies have shown PPAR with physical role in the inflammatory response in a variety of cells and a number of molecular sites. Furthermore, it shows anti-inflammatory effects by inhibiting gene expressions of cytokines,chemokines and adhesion molecules. In this review we give an overview of the mechanisms how PPAR and its ligands exert their antiinflammatory effects both at the cellular and the molecular level.
出处
《国际麻醉学与复苏杂志》
CAS
2010年第6期565-568,共4页
International Journal of Anesthesiology and Resuscitation
关键词
过氧化物酶增殖物激活受体
配体
炎症
Peroxisome proliferator-activated receptors
Ligands
Inflammation
