摘要
过氧化物酶激活受体（peroxisome proliferators-activated receptors，PPARs）超家族是核受体超家族的一员，其作用广泛，涉及脂质和脂蛋白代谢，葡萄糖代谢，细胞增殖分裂和凋亡。过氧化物酶激活受体有3种亚型α、β、γ，其中PPARα和PPARγ在缺血／再灌注损伤中起着重要的作用，现就其在肝脏的缺血／再灌注损伤中作用作一综述。
Peroxisome proliferators-activated receptors （PPARs） which has three subtypes of PPARα, PPARβ, PPARγ are nuclear receptors that function as regulators of lipid and lipoprotein metabolism and glucose homeostasis and influence cellular prolifera-tion, differentiation and apoptosis. There are many studies indicate PPARs probably protect against important organs ischemia-reperfusion injury in recent years. The aim of the present review is to highlight recent advances in the hepatic ischemia/reperfusion injury.
出处
《国际麻醉学与复苏杂志》
CAS
2010年第2期182-184,187,共4页
International Journal of Anesthesiology and Resuscitation
