摘要
目的探讨新生儿缺氧缺血性脑病(HIE)血清白细胞介素-10(IL-10)、单核细胞趋化蛋白-1(MCP-1)变化及临床意义。方法确诊为HIE的64例患儿为HIE组,其中轻度29例,中度17例,重度18例;41例健康新生儿为对照组。采用放射免疫测定法(RIA)检测IL-10,ELISA法测定血清MCP-1,并进行统计分析。结果 (1)HIE新生儿急性期血清IL-10、MCP-1水平高于对照组(P均<0.01)、恢复期(P均<0.01);恢复期与对照组比较无明显差异(P均>0.05)。(2)重度HIE患儿血清IL-10、MCP-1水平高于中度患儿(P均<0.05),高于轻度患儿(P<0.01)。(3)HIE组患儿急性期、恢复期的血清IL-10和MCP-1均呈正相关(r=0.851,r=0.832,P均<0.05);重度、中度、轻度HIE患儿血清IL-10和MCP-1呈正相关(r=0.846,r=0.835,r=0.827,P均<0.05)。结论血清IL-10、MCP-1水平可作为新生儿HIE病情严重程度和疗效判断的指标之一。
Objective To explore the changes and clinical significance of serum IL-10 and MCP-1 in newborn infants with hypoxic ischemic encephalopathy（HIE）.Methods Sixty-four newborn infants were diagnosed for HIE,which were divided into mild HIE group（n =29）,moderate HIE group（n = 17） and severe HIE group（n = 18）.41 normal newborn infants were enrolled as control group.The serum concentrations of IL-10 were detected using RIA,and the level of MCP-1 was detected with ELISA.The results were statistically analyzed.Results（1） The levels of IL-10 and MCP-1 of acute phase HIE group were higher than that of control group（P0.01 ）,also higher than that of recovery phase HIE group（P0.01）.The differences between recovery phase HIE group and control group were not significant（P0.05）.（2） In severe HIE groups,the serum IL-10 and MCP-1 levels were higher than those of moderate HIE group（all P0.05）and mild HIE group（all P0.05）.（3）The serum concentrations of IL-10 in acute and recovery phase HIE groups were positively correlated with those of MCP-1（r =0.851,r =0.832,all P0.05）,the serum concentrations of IL-10 of severe,moderate and mild HIE groups were positively correlated with those of MCP-1（r =0.846,r = 0.835,r = 0.827,all P0.05）.Conclusion Serum IL-10 and MCP-1 levels could be used as reference of disease severity and recovery effect of HIE.
出处
《疑难病杂志》
CAS
2011年第1期13-15,共3页
Chinese Journal of Difficult and Complicated Cases
