1Terrett NK,Bell AS,Brown D,et al.Sildenafil(VIAGRATM),a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction[J].Bioorg Med Chem Lett,1996,6(15):1819-1824.
3[1]Robert B, Moreland I, Abdulmaged T. Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells [J]. Life Science, 1988,62(60):PL309-318.
4[2]Bell AS, Brown D, Terrett N K. Pyrazolopyrimidinones antianginal agents [P]. EP: 463756, 1991-06-07.
5[3]Bell AS, Terrett N K. Pyrazolopyrimidinones antianginal agents[P]. EP:526004,1992-07-02.
6[4]Kunio S, Junichi I, Minoru F. Studies on hypolidemic agents.Ⅱ. Synthesis and pharmacological properties of alkyl pyrazole derivatives [J]. Chem Pharma Bull, 1984,32(4):1568-1577.
7[5]Harriet WH, Daniel FO, Donald FW. Synthesis and structure-activity relationships of pyrazolo[4,3-d]pyrimidine-7-ones as adenosine recepter antagonists [J]. J Med Chem, 1987,30:91-96.
8[1]Bell AS,Brown D,Terrett NK.Pyracolopyrinidinone agents.Eur Pat Appl.EP 463756A1.1991-06-07(CA 1992,116:255626q)
9[5]Mixcoatl-Zecuatl T,Aguirre-Banuelos P,Granados-Soto V.Sildenafil produces antin℃iception and increases morphine antin℃i ceptionyn the formalin test[J].Eur J Pharmacol,2000,400(1):81-87
3Stark S,Sachse R,Liedl T,et al.Vardenafil increase penile rigidity and tumescence in men with erectile dysfunction after single oral dose[J].Eur Urol,2001,40(2) : 181-184.
4Porst H,Young JM, Schmidt A. Efficacy and tolerability of vardenafil for treatment of erectile dysfunction in patient subgroups[J].Urology, 2003,62 (3) : 519-522.
5Hamilton HW, Ortwine DF, Worth DF,et al. Synthesis and structure-activity relationships of pyrazolo [4,3-d]pyrim- idin-7-ones as adenosine receptor antagonists [J].J Med Chem, 1987,30(1 ) :91-96.
6GRAHAM J, etal. Past, Present, and Future: A 7- Year Update of Viagra (Sildenafil Citrate) -J]. In- ternational Journal of Clinical Practice, 2005, 59(6): 680-691.
7HASEGAWA Takashi, et al. Isolation and Structural Elucidation of Cycloperltyna[il and n-Octylnortadalafil Found in a Dietary Supplement [J]. Chemical and Pharmaceutical Bulletin, 2009, 57(2): 185-189.
8URDANETA B, et al. Effects of Sildenafil Analogue on a Porcine Model of Acute Pulmonary Hypertension [J]. Perfusion, 2011, 26(6): 546-546.
9ROSEN R C, et al. PDE-5 Inhibition and Sexual Re-sponse: Pharmacological Mechanisms and Clinical Out- comes[J]. Annual Review of Sex Research, 2002, 13: 36-88.
10HOSOGAI N, HAMADA K, TOMITA M, et al. FR226807: a Potent and Selective Phosphodiesterase Type 5 Inhibitor E J ]. Europe Journal Pharmacol, 2001, 428(2): 295-302.