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西地那非合成路线图解 被引量:7

Graphical Synthetic Routes of Sildenafil
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摘要 西地那非(sildenafil,1),化学名为5-[2-乙氧基-5-(4-甲基哌嗪-1-磺酰基)苯基]-1-甲基-3-正丙基-1,6-二氢-7H-吡唑并[4,3-d]嘧啶-7-酮,是一种选择性磷酸二酯酶V(PDE5)抑制剂,是由美国Pfizer公司研发的首个口服性功能障碍治疗药物,1998年3月首次在美国上市。
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2010年第12期948-951,共4页 Chinese Journal of Pharmaceuticals
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共引文献39

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  • 1向红琳,胡高云,刘丰贤,李树华,姜素芳.枸橼酸西地那非合成工艺改进[J].晓庄学院学报(医学版),2000(1):47-48. 被引量:3
  • 2郑磊,柳志红.西地那非治疗肺动脉高压[J].中日友好医院学报,2007,21(2):113-115. 被引量:2
  • 3Stark S,Sachse R,Liedl T,et al.Vardenafil increase penile rigidity and tumescence in men with erectile dysfunction after single oral dose[J].Eur Urol,2001,40(2) : 181-184.
  • 4Porst H,Young JM, Schmidt A. Efficacy and tolerability of vardenafil for treatment of erectile dysfunction in patient subgroups[J].Urology, 2003,62 (3) : 519-522.
  • 5Hamilton HW, Ortwine DF, Worth DF,et al. Synthesis and structure-activity relationships of pyrazolo [4,3-d]pyrim- idin-7-ones as adenosine receptor antagonists [J].J Med Chem, 1987,30(1 ) :91-96.
  • 6GRAHAM J, etal. Past, Present, and Future: A 7- Year Update of Viagra (Sildenafil Citrate) -J]. In- ternational Journal of Clinical Practice, 2005, 59(6): 680-691.
  • 7HASEGAWA Takashi, et al. Isolation and Structural Elucidation of Cycloperltyna[il and n-Octylnortadalafil Found in a Dietary Supplement [J]. Chemical and Pharmaceutical Bulletin, 2009, 57(2): 185-189.
  • 8URDANETA B, et al. Effects of Sildenafil Analogue on a Porcine Model of Acute Pulmonary Hypertension [J]. Perfusion, 2011, 26(6): 546-546.
  • 9ROSEN R C, et al. PDE-5 Inhibition and Sexual Re-sponse: Pharmacological Mechanisms and Clinical Out- comes[J]. Annual Review of Sex Research, 2002, 13: 36-88.
  • 10HOSOGAI N, HAMADA K, TOMITA M, et al. FR226807: a Potent and Selective Phosphodiesterase Type 5 Inhibitor E J ]. Europe Journal Pharmacol, 2001, 428(2): 295-302.

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