摘要
三种结构新颖的杂环类维A酸,即5-四甲基四氢萘基-3-吡唑甲酸,2-甲基-5-四甲基四氢萘基-3-呋喃甲酸,1-丁基-2-甲基-5-四甲基四氢化萘基-3-吡咯甲酸的合成被报道.生物活性测试表明它们对肿瘤细胞(HL-60)有一定的抑制作用.
Syntheses of three novel heteroretinoids were reported. Novel heteroretinoids were 5-（5,6,7,8-Tetrahydro-5,5,8,8-tetramethylr-2- naphthalenyl）-3-pyrazole carboxylic acid, 2-Methyl 5-（5,5,8,8-tetramethyl-5,6,7,8-tetrahydro naphthalen-2-yl）-furan-3-earboxylie acid, 1-Butyl-2-methyl-5-（5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl）-1H-pyrrole-3-carboxylic acid. The results of biological test indicated that these compounds possessed some growth inhibition effects in leukemia cells.
出处
《华东师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2006年第2期1-6,共6页
Journal of East China Normal University(Natural Science)
关键词
维A酸
杂环
合成
生物活性
heteroretinoid
heterocycle
synthesis
biological activity
