摘要
吡唑类化合物是一类具有广泛生物活性的杂环化合物,在医药和农药领域均有商品化的品种问世.在寻找新的吡唑类化合物的过程中,以草酸二乙酯为起始原料,分别与不同的一元酮反应,经过缩合、环合、烷基化、(溴化)、水解,合成了a～d4个未见文献报道的取代吡唑甲酸乙酯、取代吡唑甲酸中间体,收率78%～90%,结构均经元素分析、1HNMR、MS和IR确证.
Pyrazole compounds are one kind of heterocyclic compounds with extensive bioactivity, and lots of pyrazole compounds have been commercialized both in the region of medicament and pesticide. In the process of find ing out some novel pyrazole compounds, a-d four novel pyrazole intermediates were synthesized. Taking diethyl oxalate as starting substance, the novel compounds can be synthesized via condensation, cyclic condensation, alkylation, （bromination） and hydrolysis reactions. The yield of products was about 78%-90%. Their structures were confirmed by elementary analysis,^1H-NMR,MS and IR.
出处
《浙江大学学报（理学版）》
CAS
CSCD
北大核心
2008年第6期641-643,647,共4页
Journal of Zhejiang University（Science Edition）
关键词
吡唑甲酸乙酯
吡唑甲酸
中间体
合成
pyrazole ethyl formate
pyrazolecarboxylic acid
intermediate
synthesis
