摘要
目的探讨直肠癌患者术前动脉插管化疗后的手术时机。方法对２７例Ｄｕｋｅｓ′Ｂ～Ｃ期直肠癌患者，选择肠系膜下动脉或左髂内动脉，以５氟脲嘧啶６００ｍｇ／ｍ２、丝裂霉素１５ｍｇ／ｍ２、表阿霉素３０ｍｇ／ｍ２灌注，评价化疗效果和毒性反应，同时监测化疗前后增殖细胞核抗原（ＰＣＮＡ）表达的变化。结果１９例患者便血症状消失或缓解。组织学效果：轻度有效（Ⅰａ）９例，中度有效（Ⅰｂ）１５例，显著有效（Ⅱ）３例。化疗毒性反应轻，多在４天后恢复。本组患者均在化疗后７～１０天内接受手术，术后恢复良好。直肠癌组织中ＰＣＮＡ呈高表达，动脉插管化疗后表达降低；化疗后４８小时显著低于化疗前；之后又逐渐升高，第７～１０天显著高于化疗前。结论术前动脉插管化疗对直肠癌行之有效，对于可一期切除癌灶的Ｄｕｋｅｓ′Ｂ～Ｃ期直肠癌，行单次动脉插管化疗后５～６天手术较为适宜。
Objective To explore inflammatory infiltration and its effects on the formation of abdominal aortic aneurysm (AAA). Methods Immunohistochemical technique was used to detect lymphocyte(CD45 positive) and macrophage (CD68 positive) infiltration while in situ hybridization was applied to investigate the mRNA expression of Matrix Metalloprotainase 9 (MMP 9) in 20 cases of human AAA and 4 cases of normal human abdominal aortas. Results Inflammatory infiltration occurred in every case of AAA with various degree, and there was a parallel tendency between the degree of injury of abdominal aortic elastin and that of inflammatory infiltration in AAA. Inflammatory infiltration was not found in normal aortas. MMP 9 mRNA was detected in macrophages and lymphocytes in all 20 cases, in smooth muscle cells in 13, and not in normal abdominal aortas. Conclusions Inflammatory infiltration attended and enhanced the formation of AAA through a complex of sequence of biochemical, cellular and immune events.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1999年第3期174-176,I007,共4页
Chinese Journal of Surgery
