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一种简便快捷的端粒酶活性原位检测法 被引量:2

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摘要 端粒酶是一种特殊的逆转录酶,其由RNA和蛋白质组成,并以本身RNA为模板催化端粒的合成和延伸〔1〕。在体细胞中除成人生殖细胞、胚胎细胞和造血干细胞外,绝大多数正常体细胞该酶呈失活状态,而大多数癌细胞和永生化细胞具有端粒酶活性。目前认为端粒酶激活与肿瘤...
出处 《临床与实验病理学杂志》 CAS CSCD 1999年第2期176-177,I018,共3页 Chinese Journal of Clinical and Experimental Pathology
基金 卫生部基金
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参考文献2

二级参考文献2

  • 1杨仕明,中华消化内镜杂志,1997年,19卷,401页
  • 2Feng J L,Science,1995年,269卷,1326页

共引文献72

同被引文献17

  • 1王伯〓等.病理学技术[M]人民卫生出版社,2000.
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  • 6Yasui W,Tahara H,Tahara E,et al.Expression of telomerase catalytic component, telomerase reverse transcriptase, in human gastric carcinomas. Japanese Journal of Cancer Research . 1998
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  • 8Yashima K,Piatyszek MA,Saboorian HM,et al.Telomerase activity and in situ telomerase RNA expression in malignant and nonmalignant lymph nodes. Journal of Clinical Pathology . 1997
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  • 10Youssef N,Paradis V,Ferlicot S,et al.In situ detection of telomerase enzymatic activity in human hepatocellular carcinogenesis. Journal of Paleopathology . 2001

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