摘要
目的系统评价他汀类药物对造影剂肾病的预防效果。方法检索1990年1月至2009年12月Cochrane图书馆、Medline数据库和EMBASE数据库,并鉴定随机对照研究的质量,按Jadad质量评分进行评定,用RevMan4.2软件进行荟萃分析。结果初步检索共有116篇相关文献,有8篇文献入选,8项研究共纳入32206例患者,6项研究的Jadad评分超过3分。荟萃分析的结果显示,他汀类药物的应用能够预防造影剂肾病(contrast induced nephropathy,CIN)的发生(OR=0.72,95%CI0.67～0.78,P<0.05);在水化的基础上应用他汀类药物与单纯水化相比,不能减少CIN的发生(OR=0.72,95%CI0.61～1.01,P=0.06)。结论他汀类药物对CIN发生有显著的预防效果。在水化基础上应用他汀类药物并不比单纯水化更加有效。
Objective The objective of this study was to assess the effectiveness of statins for prevention of contrast-induced nephropathy. Methods We searched MEDLINE,EMBASE and Cochrane databases for trials that use statins to prevent contrast-induced nephropathy. Results A total of 8 trials and 32 206 subjects were pooled. This updated meta-analysis found statins to be useful for the prevention of contrast-induced nephropathy (OR=0.72,95% CI = 0.67～0.78,P<0.05). But further analysis showed that statins with hydration were as useful as hydration only (OR=0.72,95% CI=0.61～1.01,P=0.06). Conclusions Statins were found to be useful for the prevention of contrast-induced nephropathy. But statins with hydration were as useful as placebo with hydration.
出处
《中国血液净化》
2010年第12期658-661,共4页
Chinese Journal of Blood Purification
关键词
造影剂肾病
他汀类药物
荟萃分析
Contrast-induced nephropathy
Statins
Meta-analysis
