摘要
用药物造成大鼠实验性心律失常模型,观察CGRP的作用。实验表明,CGRP可减轻二磷酸腺苷(ADP)造成的房室传导阻滞的程度,对抗窦性停搏和室颤的发生,并能促进窦性心律的恢复;CGRP可明显对抗去乙酰毛花甙丙引起的窦性停搏、房室传导阻滞和异位性节律的发生。以上结果表明,CGRP具有明显抗心律失常的作用。
We investigated the effect of CGRP on the arrhythmia induced by two drugs in rats, The result of our experiment has proved that CGRP could reduce the degrees of A-V block, resist the attack of sinus stanstill and ventricular fibrillation produced by ADP, and improve restoration of sinus rhythm. CGRP could obviously eliminate sinus stanstill and ventricular fibrillation resulted from deacetyl-lanatoside C. These evidences demonstrate that CGRP is a peptide with a strong antiarrhythmic effect.
关键词
CGRP
二磷酸腺苷
心律失常
CGRP
arrhythmia
adenosine diphosphate (ADP)
Deacetyl-Lanatoside C
