摘要
目的探讨2型糖尿病患者血清fractalkine(FKN)在糖尿病肾病(DN)不同阶段的变化及其临床意义。方法 2型糖尿病患者130例,根据尿清蛋白排泄率(UAER)分为3组:正常清蛋白尿组(NA组)45例(UAER<20μg/min),微量清蛋白尿组(MA组)43例(UAER 20～199μg/min),临床蛋白尿组(CP组)42例(UAER≥200μg/min)。另选正常对照者40例作为正常对照组(NC组)。采用酶联免疫吸附法测定3组患者及正常对照者的血清FKN水平。结果 NA、MA、CP组患者的血清FKN水平〔分别为(0.65±0.09)、(0.72±0.12)、(0.83±0.19)ng/ml〕均明显高于NC组〔(0.54±0.07)ng/ml〕,差异有统计学意义(P<0.05)。血清FKN水平随UAER的增加呈递增趋势。相关分析表明:血清FKN水平与UAER呈正相关(r=0.537,P<0.01)。结论 FKN与DN的发生、发展关系密切,FKN可能是DN发展的一个预测指标。
Objective To investigate the changesof serumfractalkine intype2 diabetic mellitusduring different stages as well as its clinical significance.Methods According to urinary albumin excretion rate（UAER）,130 cases with T2DM were divided into three groups： 45 cases of normal albuminuria group（NA）,43 cases of micro albuminuria group（MA） and 42 cases of clinical albuminuria group（CP）.40 healthy subjects were taken as the normal controls.Serum FKN was measured by ELISA in the three groups and 40 normal controls.Results FKN concentrations were significantly higher in patients with type 2 diabetes mellitus than those in normal controls（P 0.05）.The level of FKN increased as the increase of UAER.Serum FKN was positively correlated with UAER（r = 0.537,P 0.01）.Conclusion FKN might play a very important role in the initiation and progression of DN,and it might be a prediction factor in the development of DN.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第33期3748-3750,共3页
Chinese General Practice
