摘要
目的观察替勃龙治疗对绝经期妇女颈动脉内中膜厚度及动脉粥样硬化斑块面积的影响。方法100例绝经后妇女被分为绝经期治疗组50例,每天口服替勃龙(利维爱)2.5mg;50例未进行激素治疗的作为对照组。采用无创性高分辨超声分别检测颈动脉内中膜厚度(IMT)及动脉粥样硬化斑块面积。结果治疗组颈总动脉的IMT下降了27.1%,从治疗前的(0.73±0.18)mm(95%CI0.68～0.78mm),下降到治疗后的(0.57±0.21)mm(95%CI0.51～0.63mm)(P<0.01);颈动脉粥样硬化斑块面积明显减少(P<0.05)。结论替勃龙治疗后胆固醇、LDL降低,IMT变薄,动脉粥样硬化斑块面积减少,认为有降低动脉硬化的作用。
【Objective】To assess the effect of Tibolone treatment on IMT and plaque area of carotid in postmenopausal women as sonographic markers of atherosclerosis.【Methods】A total of 100 healthy menopausal women were included in this study,subjects were allocated in two groups：group T （n=50） received 12.5 mg/d of Tibolone daily and group C （n=50） was a free-treatment control group. Noninvasive measurements of intima-media thickness （IMT） and plaque area of carotid were made with ultrasound at baseline and after one year of Tibolone treatment. 【Results】One year of Tibolone treatment decreased the IMT of the CCA （mean±SD） from （0.73±0.18） mm （95% confidence interval [CI],0.68～0.78） to （0.57±0.21） mm （95% CI,0.51～0.63） by 27.1% （P〈0.01）. Carotid atheromatous plaque area regressed significantly （P〈0.05）.【Conclusion】Tibolone administration reduced IMT and atheromatous plaque area of carotid and plasma lipids. These were regarded to have the effect of anti-atherosclerosis.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第1期84-86,共3页
China Journal of Modern Medicine
关键词
替勃龙
绝经
内中膜厚度
动脉粥样硬化
斑块
Tibolone
menopause
intima-media thickness
atherosclerosis
plaque
