摘要
目的观察不同剂量利维爱对绝经后妇女乳腺及血脂的影响。方法63例绝经后妇女,分为两组:A组利维爱1.25mg/d,B组利维爱0.625mg/d,连续用药1年。用药前、后进行Kupperman评分、超声检查乳腺及检测血脂水平。结果A组症状改善程度明显优于B组,但服药1年后比较,差异无显著性(P>0.05)。A组用药后乳腺腺体层厚度较用药前组增加,差异有显著性(P>0.05),乳腺导管差异无显著性(P>0.05);B组用药前、后比较,差异均无显著性(P>0.05)。A组TC、TG、LDL-C治疗前、后差异有显著性(P>0.05),HDL无明显变化;B组治疗前后差异无显著性(P>0.05)。结论两种小剂量利维爱均可以缓解绝经后症状,达到HRT的治疗作用。利维爱0.625mg/d对乳腺刺激小,利维爱1.25mg/d可明显降低血脂水平,从而可降低绝经期妇女发生心血管疾病的危险。
Objective To observe the effects of different dose Livial on the breasts and blood-fat of postmenopausal women. Methods 63 cases of postmenopausal women were divided into two groups： group A was given Livial 1.25mg every day and group B was given Livial 0.625mg every day for one year. Kupperman score,Mammary uhrasonography and blood-fat of all patients before and after administration were evaluated. Results The menopausal symptoms significantly allevi- ated, group A was better than group B,but there was no significant difference between the two groups after one year （P〈0.05）. After administration,breast glandular section thickness in group A was larger than before,there was significant difference between them （P〈0.05）,but breast duct width was no significant difference（P〈0.05）.The significant differences of TC ,TG,LDL-C in group A were found （P〈0.05）,but there was no marked change of HDL; In group B, there was no significant difference （P〈0.05）. Conclusion The two low dose Livial could alleviate the menopausal symptoms. Livial 0.625mg every day is less irritation on mammary gland, Livial 1.25mg every day could obviously degrade blood-fat, so it could lower the risk of cardiovascular disease of postmenopausal women.
出处
《药品评价》
CAS
2007年第6期421-424,共4页
Drug Evaluation
关键词
绝经
激素替代治疗
乳腺
脂类
Menopausal symptoms
Hormone replacement therapy mammary
Mammary gland
Lipids
