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更年期妇女颈动脉病变与血脂相关性研究 被引量:4

A study of relativity between carotid atherosclerosis and blood lipids in menopause women
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摘要 目的探讨更年期妇女颈动脉病变与血脂水平的相关关系。方法随机选取健康体检的更年期妇女318名,依据其血脂检测结果分为血脂异常组152名,血脂正常组166名,利用二维彩色多普勒超声显像仪检测颈动脉内中膜厚度及动脉粥样斑块的发生情况。分析血压、体质指数与血脂水平的关系。结果更年期妇女中颈动脉病变检出率达50.94%,其中粥样斑块形成率达27.04%。血脂异常组中受检者的血压、体重指数、颈动脉内中膜厚度以及粥样斑块的发生率均高于正常对照组(P<0.01,P<0.05)。结论颈动脉粥样硬化及内中膜增厚在围绝经期妇女中有较高的发生率,尤其在有血脂异常的妇女中发生率更高。提示我们对围绝经期妇女应加强健康教育,定期进行健康检查,特别是血脂检测及颈动脉超声检查,以便早期发现异常,采取相应的干预措施,预防心脑血管病的发生,提高妇女的生存质量。 Objective To investigate the relationship between carotid atherosclerosis,the intimal medial thickness (IMT) and the level of lipids in menopausal women. Methods 318 cases of menopausal women were randomly selected for health examination and divided into two groups: 152 cases with abnormal lipid level as test group and 166 cases with normal lipid level as contrast group. 2D color Doppler ultrasonic angiograph was used to examine the intimal medial thickness and the development of atheromatous plaque. The relationship between blood pressure ,body mass index (BMI) and the lever of lipids were analyzed. Results The ratio of intimal medial thickness was 50.94% and atheromatous plaque was 27. 04% in menopausal women. The blood pressure, BMI,the intimal medial thickness and rate of development of atheromatous plaque in test group were significantly higher than those in contrast group ( P 〈 0. 001 ). Conclusion The rate of scleratheroma of carotid and the intimal medial thickness is high in menopausal women, especially in those with abnormal lipids. In order to find the abnormity early and carry on treatment correspondingly, education and health examination particularly blood -fat and Doppler ultrasonic inspection should be performed regularly.
出处 《临床和实验医学杂志》 2007年第11期27-28,共2页 Journal of Clinical and Experimental Medicine
关键词 超声波检查 更年期 血脂 动脉粥样硬化 USE Carotid atherosclerosis Lipids
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  • 1Mikkola T, Viinikka L, Ylikorkala O. Estrogen and postmenopausal estrogen/progestin therapy : effects on endotheliurn-dependent prostacyclin nitric oxide and endothelin-1 production[J], Eur J Ohstet Gynecol Reprod Biol, 1998, 79:75-82.
  • 2Ruehlmann DO, Steinert JR, Valverde MA et al. Environmental estrogenic pllutants induce acute vascular relaxation by inhibiting L-type Ca^2+ channels in smooth muscle cells[J], FASEB J, 1998,12: 613-619.
  • 3Haynes MP,Sinha D, Russell Ks,et al. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells. Circ Res,2000,87:677-682.
  • 4Konukoglu D,Sserin O,Erean Met al. The relationship between plasma viscosity and cholesterol in postmenopausal women on hormone replacement therapy[J]. Clin Hemorheol Mierocire, 2000,22:223-228.
  • 5Warner M, Nilsson S, Gustafsson JA. The estrogen receptor family[J], Curr Opin Obstet Gynecol, 1999,11 : 249-254.
  • 6Hodges YK, Tung L, Yan XD,et al. Estrogen receptor alpha and beta: prevalence of estrogen receptor beta mRNA in human vascular smooth muscle and transcriptional effect [J], Circulation, 2000,101 : 1792-1798.
  • 7Gustafsson JA. Novel aspects of estrogen action. J Soc Gynecol Investig[J], 2000,7: S8-9.
  • 8Simincini T, Hafezi-Moghadam A, Brazil DP,et al. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase [J]. Nature, 2000, 407: 538-541.
  • 9Jovanovic A, Jovanovic S, Grbovic L. Characterization of oxytocin actions in guinea-pig isolated uterine artery: the effect of pregnancy[J], Eur J Pharmacol, 1998,343 : 35-42.
  • 10Teoh H, Quan A, Leung SW. Diffirential effects of 17 betaestrodiol and testosterone on the contractile responses of porcine coronary arteries [J], Br J Pharmacol, 2000, 129 :1301-1308.

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