摘要
目的探讨肺心病患者血小板活化功能的变化及川芎嗪对其影响。方法４６例慢性肺心病急性加重期患者随机分为２组，Ａ组２４例进行常规治疗；Ｂ组２２例在常规治疗基础上给予川芎嗪注射液１２０ｍｇ／ｄ静滴，疗程均为１５日。治疗前后应用流式细胞仪测定外周血血小板ＣＤ６２Ｐ及血小板膜Ｆｇ含量，并以２０例健康人作对照。结果肺心病患者血小板ＣＤ６２Ｐ及血小板膜Ｆｇ含量均显著高于健康人（Ｐ＜０．０１），治疗后显著低于治疗前（Ｐ＜０．０１），治疗后Ｂ组显著低于Ａ组（Ｐ＜０．０１）。结论肺心病患者血小板活化程度增加在肺心病发病中起一定作用，川芎嗪可有效降低肺心病患者血小板活化功能。
Objective To study the change of and the effects Ligustrazine on acivation of platelet
in patients with co pulmonale. Methods 46 cases of cor pulmonale in exacerbation were
randomly divided into 2 groups,group A(n=24)was treated by routine therapy;group B(n=22)was
treated by routine therapy + ligustrazine,120mg/d,i.v. The therapeutic courses in both groups
were 15 days Before and after treatment,positive platelet percents of pselectin(CD62Pand
bound fibrinogen(Fg) in peripheral blood were examined by flow cytometric immunology
respectively.20 healthy volunteer served as control group. Results CD62 Pand Fg in patients
with cor pulmonale before and after treatment were higher significantly than those in contral
group(P<001),CD62Pand Fg in patients with cor pulmonale after treatment decreased markedly
as compared to those before treatment(P<001),CD62P and Fg in group B after treatment were
significantly lower than those in group A after treatment(P<001).HZConclusion These results
suggest that activated platelet may be involved in pathogenesis of cor pulmonale and
ligustrazine can decrease activated platelet activation effectively in patients with cor
pulmonale.
出处
《临床内科杂志》
CAS
1999年第4期203-204,共2页
Journal of Clinical Internal Medicine
关键词
肺心病
血小板
川芎嗪
急性加重期
药物疗法
Pulmonary healt diseasePlateletPselectin Fibrinogen Ligustrazine
