摘要
目的研究胆囊结石胆囊组织中粘蛋白5AC(mucin 5AC,MUC5AC)和表皮生长因子受体(epidermalgrowth factor receptor,EGFR)的表达,探讨胆囊结石的形成。方法采用免疫组化法和图像分析检测54例胆囊结石胆囊组织、24例对照胆囊组织(来自于壶腹部癌或胰头癌手术切除胆囊)MUC5AC,EGFR的表达情况。结果 MUC5AC和EGFR在胆囊结石胆囊组织中的表达较对照胆囊组织显著增高(P<0.05)。EGFR阳性表达区域和MUC5AC阳性表达区域呈正相关(rs=0.978,P<0.001)。结论 MUC5AC,EGFR可能与胆囊结石形成有关。
Objective To probe the formation of cholecystolithiasis by studying the expression of mucin 5AC（MUC5AC） and epidermal growth factor receptor（EGFR） in gallbladder of cholecystolithiasis.Methods Expression of MUC5AC and EGFR were examined with immunohistochemical analysis and image analysis in gallbladders from 54 specimen of cholecystolithiasis and 24 specimen of control which come from duodenopancreatectomy.Results Weak signal of MUC5AC and EGFR were detected in the control cholecysts in comparison with stronger signal in the cholecysts of cholecystolithiasis（P0.05）.There was significant positive correla-tion between the expression of the MUC5AC and the expression of the EGFR in 20 specimen（rs=0.978,P 0.001）.Conclusion It is suggested that there may be correlation between MUC5AC,EGFR and the formation of cholecystolithiasis.
出处
《肝胆胰外科杂志》
CAS
2010年第5期392-394,共3页
Journal of Hepatopancreatobiliary Surgery
关键词
粘蛋白5AC
表皮生长因子
胆囊结石
mucin 5AC epidermal growth factor（EGFR） cholecystolithiasis
