摘要
目的研究济宁地区HPV不同亚型在宫颈病变中的分布情况,以探讨宫颈病变患者HPV基因分型。方法对2010年3月至2010年8月来济宁医学院附属医院就诊的479例患者进行HPV分型检测。结果 479例样本中,检出HPV阳性患者150例,其中高危型(不包括复合型)HPV(16、18、31、33、39、45、52、56、58、59、68)66例,低危型(不包括复合型)HPV(6、11、43、44)36例,中国人群常见型HPV(53、66、CP8304)10例,复合型HPV38例。高危型HPV16(17.3%)、58(10%),低危型HPV11(17.3%),复合型(25.8%)的感染率比较高。结论济宁地区人群HPV感染亚型16、58、11较常见,为研制适合中国人群的HPV预防和治疗性疫苗提供数据。
Objective To investigate the distribution of the different subtype of human papillomavirus （HPV） to cervical disease in Jining, Shandong province. Methods The gene type of HPV were detected by PCR- channelization hybridization. Results From 479 patients with cervical lesions, the HPV positive were detected in 150 cases, among which, there were 66 cases who had been infected by the type of high-risk HPV （16, 18, 31, 33, 39, 45, 56, 58, 52, 59, 68） while there were 36 cases who had been infected by the type of low-risk I-IPV （6, 11, 43, 44）. Mixed infection of HPV was 38 cases. In the patients infected high-risk HPV, the more common type of HPV were type 16（17.3%） or type 58（10%） while in the patients infected low-risk HPV, the more common type of HPV were type 11 （17.3%）. The mixed infection of HPV were most common（25.8%）. Conclusion The infection of HPV subtype 16, 58, 11 were more common in Jining, Shandong province.
出处
《分子诊断与治疗杂志》
2010年第6期390-393,共4页
Journal of Molecular Diagnostics and Therapy
关键词
HPV基因分型
宫颈病变
年龄关系
HPV genotyping
Cervical pathological changes
Relationship of age
