摘要
目的：研究女性人乳头瘤病毒（HPV）的感染现状及其与年龄的相关性。方法：收集大连地区4281例成年女性宫颈脱落细胞标本进行HPV定性检测并加以分型,结合年龄信息进行统计分析。结果：4 281例标本中,HPV阳性标本974例,阳性率为22.75%;在不同年龄分组中,以21-25岁感染率（40.67%）最高。共检出20种基因型,包括低危型HPV6、11、42、43和高危型HPV16、18、31、33、35、45、51、52、53、56、58、59、66、68、73、83,低危型以HPV43感染为主,高危型以HPV16感染为主。974例阳性标本中,单一感染689例（占70.74%）,双重感染211例（占21.66%）,多重感染77例（占7.91%）;低危型感染166例（占17.04%）,高危型感染692例（占71.05%）,混合感染122例（占12.53%）。结论：大连地区女性HPV感染具有明显的亚型和年龄分布异质性,提示宫颈癌的筛查及防治应同时考虑HPV分型和年龄因素。
Objective： To research the current situation of human papillomavirus（ HPV） infection in female patients and its correlation with age. Methods： The cervical exfoliated cell specimens of 4 281 adult women were collected in Dalian area,then HPV qualitative detection and typing were performed,a statistical analysis was conducted combing with age. Results： Among 4 281 specimens,974 specimens were found with positive HPV,the positive rate was 22. 75%; among different age groups,the infection rate in 21- 25- year- old group was the highest（ 40. 67%）; a total of 20 kinds of genotypes were detected,including low risk HPV 6,11,42,43 and high risk HPV16,18,31,33,35,45,51,52,53,56,58,59,66,68,73,83; the predominant low risk HPV genotype and high risk HPV genotype were HPV 43 and HPV 16,respectively; among 974 specimens with positive HPV,the proportions of single infection,double infection and multiple infection were 70. 74%（ 689 specimens）,21. 66%（ 211 specimens） and 7. 91%（ 77 specimens）,respectively; the proportions of low risk infection,high risk infection and mixed infection were 17. 04%（ 166 specimens）,71. 05%（ 692 specimens） and 12. 53%（ 122specimens）,respectively. Conclusion： The subtype- specific and age- specific distributions of HPV infection in Dalian area have obvious heterogeneity,which indicates that HPV genotypes and age should be considered in screening,prevention and treatment of cervical cancer.
出处
《中国妇幼保健》
CAS
北大核心
2014年第16期2558-2560,共3页
Maternal and Child Health Care of China
关键词
人乳头瘤病毒
基因分型
年龄分布
宫颈癌
Human papillomavirus Gene subtype Age distribution Cervical cancer
