摘要
目的探讨宫颈病变患者HPV基因亚型转阴情况。方法对2010年5月1日至2011年8月30日于济宁医学院附属医院就诊的3224例患者进行HPV分型检测。结果 3224例样本中,检出HPV阳性者892例,其中高危型HPV(16、52、58、53、31、66、68、33、39、18、56、59、45、51、35)676例,低危型HPV(6、11、44、CP8304)216例。高危型HPV16(23.1%)及HPV52(13.1%)感染率较高。通过对复查患者进行统计,发现低危型HPV11转阴率(87.3%)较高,高危型HPV16和52(67.7%,67.4%)次之,HPV58(43.5%)较低。结论鲁西南地区人群HPV感染亚型除16、58、11外,亚型52也较常见。低危型HPV11感染的转阴率较高,且高危型HPV感染也存在一定的转阴率。
Objective To investigate the circumstance of human papillomavirus gene subtypes changing into negativity. Methods 3224 cervical cases were detected by the HPV Genotyping System obtained in Affiliated Hospital of Jining Medical College from March 1st, 2010 to August 30th, 2011. Results 892 cases out of 3224 patients with cervical disease were identified as HPV positive. There were 676 patients with high-risk type HPV（16, 52, 58, 53, 31, 66, 68, 33, 39, 18, 56, 59, 45, 51, 35） and 216 patients with low-risk type HPV（6, 11, 44, CP8304） among those cases. The infection rates of high-risk type HPV16 and HPV52 were quit high, 23.1% and 13.1%, respectively. According to the statistics on the re-examined patients, the negative conversion rate of low-risk type HPV11（87.3%） was the highest, which was followed by high-risk HPV 16 and 52（67.7%, 67.4%） , and HPV58（43.5%） was the lowest. Conclusion Besides HPV subtype 16, 58, 11, subtype 52 was very common in the southwest of Shandong Province. The negative conversion rate of low-risk HPV infection was higher than that of high-risk HPV, and the negative conversion rate of high-risk HPV infection still existed to some extend.
出处
《分子诊断与治疗杂志》
2012年第1期23-25,共3页
Journal of Molecular Diagnostics and Therapy
关键词
HPV基因分型
宫颈病变
转阴情况
HPV genotyping
Cervical disease
The circumstance changing into negativity
