摘要
目的:对静脉注射后大鼠体内川芎嗪药动学特征进行研究。方法:流动相为甲醇-0.05 mol/L醋酸-醋酸钠的水溶液(50∶50,V/V),流速为1.0 mL/min,紫外检测波长为280 nm。结果:川芎嗪静脉注射后体内血药浓度-时间过程符合二房室药动学模型,药物分布与消除半衰期分别为49.36 min与91.85 min,平均滞留时间MRT0～∞为141.61 min,AUC0～∞为7521.70μg·min/mL。结论:盐酸川芎嗪静脉注射后,在大鼠体内的药动学符合二房室模型,分布和消除均较快。
Objective： To investigate the pharmacokinetics behaviour of tetramethylpyrazine（TMP） by intravenous administration in rats.Methods： Methanol-0.05 mol/L acetate buffer solution（50∶ 50,V/V） was used as mobile phase with a flow rate of 1.0 mL/min.The UV detection wavelength was 280 nm.Results： The profile of TMP in blood fitted a two-compartment model.The half time of drug distribution and elimination was short.The mean residence time MRT0 ～∞ was 141.61 min,and the AUC0 ～∞ was 7521.70 μg·min/ mL.Conclusion： After intravenous injection,the pharmacokinetics behaviour of TMP fit a two-compartment model in rats.Both the dis-tribution and the elimination are fast.
出处
《中药材》
CAS
CSCD
北大核心
2010年第10期1599-1602,共4页
Journal of Chinese Medicinal Materials
基金
广东省中医药管理局项目(2009177)
暨南大学药学院211工程和重点实验室创新研究项目
关键词
川芎嗪
药动学
HPLC
Tetramethylpyrazine
Pharmacokinetics
HPLC
