摘要
从机体对药物作用特征的角度，探索中医证本质。同步研究了健康与利血平致脾虚大鼠的血液流变学及磷酸川芎嗪（ＴＭＰＰ）灌胃后的药物动力学（药动学）。在本实验条件下与健康组相比，脾虚组的药动学特征为：ＴＭＰＰ在体内的空间处置状态由双室变为单室模型；药物浓度值增加（Ｐ＜０．０５、０．０１）；血药浓度－时间曲线下面积（ＡＵＣ）增强（Ｐ＜０．０１）。７项血液流变学指标（Ｐ＜０．０５～０．０１）示脾虚大鼠处于典型的“浓、粘、聚、凝”的血瘀状态。结论：脾主运化、四肢、肌肉与脾之气虚血瘀可能是脾虚大鼠特征性药物动力学的机制之一；为“辩证药动学”假说提供了初步依据。
In this experiment,the essence of Spleen Deficiency Syndrome(SDS) was explored with the rat model of SDS using tetramethylpyrazine(TMP).120 Wistar rats were divided into two groups,60 each for control and test group,they were treated with normal saline and reserpine respectively.The hemorheological parameters were also studied in 6 each of both groups.The pharmacokinetic properties were investigated in the remaining control group and test group.Results:(1)Twocompartment open model of the control group was turned into that of one-compartment in test group;(2)The SDS model significantly affected the absorption and distribution of TMP in rats.AUC was much higher and serum concentration of TMP increased significantly than that of control.Hemorheological parameters(viscosity of whole blood, fibrinogen,etc.)increased significantly(p<0.05-0.01),it demonstrated that the SDS model was in a state of Blood Stasis.It might be one of the pharmacokinetic mechanisms of TMP in the SDS model of rats.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1994年第3期159-161,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金
关键词
脾虚
川芎嗪
血液流变学
Spleen Deficiency, tetramethylpyrazine,pharmacolinetics,blood hemorheology
