摘要
目的:研究野漆树根对四氯化碳致小鼠急性肝损伤模型、大鼠急、慢性肝损伤模型的抗肝损伤作用。方法:以灌胃CCl4复制小鼠急性肝损伤模型、皮下注射CCl4复制大鼠急、慢性肝损伤模型。以血清谷丙转氨酶(ALT),肝组织丙二醛(MDA)、超氧化物歧化酶(SOD)含量、肝羟脯氨酸(hyp)等为指标结合肝组织病理学检查,观察野漆树根的抗肝损伤作用。结果:野漆树根对CCl4造成的急性肝损伤小鼠和急性肝损伤大鼠ALT,AST活性升高有显著的降低作用(P<0.05,P<0.01);野漆树根可显著降低CCl4致急性肝损伤大鼠肝组织MDA水平(P<0.05,P<0.01),升高肝组织SOD水平(P<0.01);野漆树根可显著降低由CCl4造成的慢性肝损伤大鼠肝羟脯氨酸含量(P<0.01)。结论:野漆树根具有显著的抗肝损伤作用。
Objective：To investigate the protective efects of Field Lacquertree root against liver damage by CCl4 in rodents.Methods：Affused entogastric CCl4 to build the acute mouse liver injury mode1,Injected hypodermic CCl4 to set up the acute rat liver injury model and sub·acute rat liver injury mode1.Field Lacquertree root was given intragastrically in the treated groups.At the end oftest,concentrations of ALT and AST in serum,activity of SOD and the contents of MDA and hyp in liver homogenate were detecte.detected.Liver was excised and fixed in formalin for histopathologleal examination.Results：For the acute liver damage animals induced by CCl4,Field Lacquertree root could significantly inhibit the elevation of ALT and AST levels in seram（P〈0.05,P〈0.01） and MDA content in liver homogenate（P〈0.05,P〈0.01）,and could increase the content of SOD in liver homogenate（P〈0.01）,Field Lacquertree root could significantly decreased contents of hydroxyproline in liver homogenate in sub·acute rat liver injury mode1（P〈0.01）.Conclusion：Field Lacquertree root showed a marked protective effect against liver damage.
出处
《江西中医学院学报》
2010年第5期69-71,共3页
Journal of Jiangxi College of Traditional Chinese Medicine
基金
江西省卫生厅中医药课题资助项目(编号:2007A075)
关键词
野漆树根
抗肝损伤
实验研究
Field Lacquertree root
Hepatic injury
Experimental study
