摘要
近来的研究表明，喹诺酮类抗菌药物与细菌ＤＮＡ分子间的结合可能受到介质离子强度等因素的影响［１，２］．人们对镁（Ⅱ）在药物与ＤＮＡ结合中所起的作用虽有研究［１，３］，但多是从药理学的角度进行的［１～４］．环丙沙星（ＣＰＦＸ）是目前临床上广泛使用的新一代...
Using the method of fluorescence, the binding constants of ciprofloxacin(CPFX)Mg()and CPFXcalf thymus DNA(C. T. DNA), the formed quantity and the forming condition of ternary complex of CPFXMg()C.T.DNA have been determined. Adding Mg() to the binary system of CPFX with C.T.DNA, the binding quantity of CPFX with C.T.DNA increases to the largest, then decrease up to zero in the end as the increase of the concentration of Mg(). The result shows the amount of CPFX bound to C.T.DNA is modulated by Mg(), and in the concentration of Mg() precented in eucaryotic organism cytoplasm, CPFX has no obvious combination with C. T. DNA.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1999年第4期584-586,共3页
Chemical Journal of Chinese Universities
