摘要
过氧化物酶体增殖物激活受体(peroxisome proliferators-activated receptor,PPAR)属于核受体超家族成员之一,PPAR有3种亚型,即PPARα、PPARβ和PPARγ。近年研究发现肿瘤细胞中普遍表达PPARγ,而且PPARγ配体可以抑制肿瘤细胞增殖,诱导肿瘤细胞凋亡,因此PPARγ被认为是肿瘤治疗的新靶点。本文就PPARγ与肿瘤细胞凋亡的研究进展作一简要综述。
Peroxisome proliferators-activated receptors（PPARs） are members of the nuclear receptor superfamily which consist of the three isoforms-PPARα,PPARβ and PPARγ.Recent studies indicated that PPARγ and ligands of PPARγ generally expressed in cancer cells which inhibited proliferation and induced apoptosis of cancer cells.So PPARγ was regarded as a new target for cancer therapy.This article briefly reviewed the progress of PPARγ and apoptosis of cancer cells.
出处
《现代生物医学进展》
CAS
2010年第21期4152-4155,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金(No.30771793)
关键词
过氧化物酶体增殖物激活受体Γ
肿瘤细胞
凋亡
peroxisome proliferators-activated receptor gamma（PPARγ ）
cancer cells
apoptosis
