摘要
目的观察帕罗西汀治疗卒中后抑郁焦虑症状的疗效、安全性，及其对肢体功能康复的影响。方法88例急性脑卒中后抑郁焦虑患者按数字表法随机分为帕罗西汀组42例和对照组46例，对照组给予脑血管病常规治疗，帕罗西汀组在对照组治疗的基础上给予帕罗西汀20mg，1次／d，分别于治疗后4、6周末进行汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）和神经功能缺损、生活能力状态等评定。结果治疗后4、6周，两组治疗后HAMD、HAMA量表评分、神经功能缺损评分及B1指数均较治疗前明显改善（均P〈0．05），帕罗西汀组较对照组改善更为明显（t=3．521、2．604、2．773、2．683、3．637、3．781、3．042、2．913，均P〈0．05）。未发生严重不良反应。结论帕罗西汀治疗脑卒中后抑郁焦虑疗效可靠，无明显不良反应，且能加速肢体功能康复。
Objective To study the efficiency, safety, and its impact on the functional rehabilitation of the selective 5-serotonin reuptake inhibitor（SSRI） drugs paroxetine in treatment patients with poststroke depression and anxiety. Methods The acute stroke patients at our Neurology department and old-age cadres department were selected, in which have 88 cases of poststreke patients with depression and anxiety, which were divided into paroxetine group and the control group. Paroxetine group was given Seroxat 20 mg, 1 time/d ＋ conventional treatment of cerebrovascular disease. The control group was gaven conventional treatment of cerebrovascular disease only. After 4 weeks, 6 weeks of treatment, we assessed Hamilton Depression Rating Scale （ HAMD）, Hamilton Anxiety Scale （ HAMA）, neu- rological deficit and the state of living ability were assessed. Results There were significant differences in improve- nent of depression and anxiety,neurological deficit and the capacity of the state of life between the Paroxetine group and the control group the control group of 4 weeks treatment compared with before treatment （ all P 〈 0. 05 ） ; Compared with before treatment,the control group of 6 weeks treatment compared with before treatment （all P 〈 0.05 ） ;Paroxe- tine group of 4 weeks treatment compared with before treatment（ all P 〈 0. 05 ） ;Paroxetine group of 6 weeks treatment compared with before treatment （ all P 〈 0.05 ）, and Paroxetine group control is obvious Improved （ all P 〈 0. 05 ）. Conclusion Using Parexetine to treat poststroke patients with depression and anxiety, not only could significantly improve symptoms of depression and anxiety, hut also speed up the rehabilitation of limb function, efficacy reliable, and had no significant adverse reactions. So,it was an ideal medcine for poststroke patients with depression and anxiety.
出处
《中国基层医药》
CAS
2010年第21期2953-2955,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
脑血管意外
抑郁
焦虑
共病
帕罗西汀
Cerebrovascular accident
Depression
Anxiety
Paroxetine
