摘要
目的探讨天麻素注射液联合盐酸氟西丁治疗卒中后抑郁的临床效果及安全性。方法对符合条件的102例卒中后抑郁患者随机分为两组，每组51例，天麻素注射液（600mg，1次／d，静脉滴注，疗程14d）联合盐酸氟西丁（20mg，1次／d，口服，30d）组为治疗组。单用盐酸氟西丁（20mg，1次／d，口服，30d）为对照组。观察两组患者的症状及体征变化以及汉密尔顿抑郁量表评分，评价疗效。结果治疗组痊愈9．8％（5／51），显著进步52．9％（27／51），进步27．5％（14／51），无效9．8％（5／51），总有效率90．2％（46／51）。对照组痊愈2．0％（1／51），显著进步11．7％（6／51），进步66．7％（34／51），无效19．6％（10／51），总有效率80．4％（41／51）。治疗组的疗效优于对照组，二者比较差异有统计学意义（X2=13．03，P〈0．05）。治疗组不良反应发生率为3．92％（2／51），对照组为25．5％（t3／51），两组比较差异有统计学意义（X2=9．64，P〈0．01）。结论天麻素注射液联合盐酸氟西丁是治疗卒中后抑郁的一种疗效确切且副反应少的治疗方法。
Objective To investigate the therapeutic effects and adverse reaction of Gastrodin Injection combined with Fluoxitine （Prozac） in the treatment of post-stroke depression （PSD）. Methods One hundred and two patients with PSD were randomly allocated into two groups： 51 cases in the Gastrodin Injection and Fluoxitine combination group （treatment group） ,51 cases in Fluoxitine Group （control group）. The treatment group was treated by intravenous injection of 600 mg/d Gastrodin （14 days） plus oral administration of 20 mg/ d Fluoxitine （ 30 days ）. The control group was only treated by oral administration of 20 mg/d Fluoxitine （ 30 days）. The therapeutic effects were evaluated by the observations of the changes of symptoms and signs and Hamilton Depression Scale （HAMD） respectively in the two groups. Results The cured, effective, improved and invalid rates were 9. 8% （5/51） ,52. 9% （27/51） ,27.5% （ 14/51 ） and 9. 8% （ 5/51 ） respectively in the treatment group and 2. 0% （2/51）, 11.7% （6/51）, 66. 7% （ 34/51 ） and 19.6% （ 10/51 ） in the control Group. The total effective rate in the treatment and the control groups were 90. 2% （46/51） and 80. 4% （41/51） respectively. The therapeutic effect was better in the treatment group than in the control group, and there was significant difference observed between the two groups （X2 = 13.03, P 〈 0. 05 ）. The rate of adverse reaction was significantly lower in the treatment group than in the control group （3.92% （2/51） vs. 25.5% （ 13/51 ） ,X2 = 9. 64, P 〈 0. 01 ）. Conclusion Gastrodin Injection in combination of Fluoxitine, with low adverse reation rate, is an effective therapeutic method for the treatment of PSD.
出处
《中国综合临床》
2013年第7期734-736,共3页
Clinical Medicine of China
关键词
天麻素
卒中
卒中后抑郁
Gastrodin
Stroke
Post-Stroke
Depression
