摘要
为探讨多形核白细胞（ＰＭＮ）浸润在急性胆管炎肝损害中的作用，作者观察了急性胆管炎时肝脏ＰＭＮ聚集与肝损害的关系。结果显示：急性胆管炎时大鼠肝组织ＰＭＮ数量进行性增多，开始主要聚集在肝窦，１２小时后穿越肝窦内皮细胞在肝细胞周围聚集并逐渐增多，肝细胞变性坏死，动物２４小时存活率仅为４０％。消耗循环ＰＭＮ使肝脏功能损害得到明显改善，肝坏死面积减少，动物存活率提高。表明肝脏ＰＭＮ浸润在胆道感染肝损害发生中具有重要作用。
The mumber of Polymorphonuclear leukocyte (PMN) in hepatic tissue increased in the rats with cholangitis, PMN infiltration was mainly in the hepatic sinus in the early stage; and PMN infiltration presented around the hepatocytes 12 hours after infection. Degeneration and necrosis of the hepatic cells was also observed in the rats with acute cholangitis. Only 40 percent of the rats survived 24 hours after infection. Depletion of circulating PMN decreased the damage and necrosis of hepatocytes and improving the survival rate of the infected rats. The results suggest that PMN infiltration plays an important role in hepatic damage in acute cholangitis.
出处
《中国普外基础与临床杂志》
CAS
1999年第3期146-147,共2页
Chinese Journal of Bases and Clinics In General Surgery
关键词
多形核白细胞
肝损害
胆管炎
Cholangitis Hepatic damage Polymorphonuclear
