摘要
目的：探讨慢性乙型肝炎（乙肝）患者外周血单个核细胞（ＰＢＭＣ）中膜白介素２受体（ｍＩＬ２Ｒ）在静息状态和诱导状态的表达水平及其与ＨＢｅＡｇ的关系。方法：用生物素链霉亲和素系统检测１０８例慢性乙肝患者ＰＢＭＣ的ｍＩＬ２Ｒ，并平行测定患者血清中ＨＢｅＡｇ。结果：在静息和诱导状态下，慢性乙肝患者的ｍＩＬ２Ｒ水平均低于正常对照组（Ｐ＜０．０５）；ＨＢｅＡｇ（＋）患者的ｍＩＬ２Ｒ水平也低于正常对照组（Ｐ＜０．０５和Ｐ＜０．０１）。结论：慢性乙肝患者ｍＩＬ２Ｒ表达水平低下。
Objective:To study the level of membrane interleukin 2 receptor(mIL 2R) in peripheral blood mononuclear cells(PBMC) of chronic hepatitis B patients during silent and PHA induced phase and its association with HBeAg.Methods:In 108 patients with chronic hepatitis B mIL 2R in PBMC was detected by biotin streptavidin(BSA) assay and HBeAg in serum.Results:The level of mIL 2R in patients with chronic hepatitis B during silence and PHA induced phase were significantly lower than that in normal controls( P < 0.05 ) and the level of mIL 2R in patients with HBeAg(+) were also lower than those in normal controls( P < 0.05 and P <0.01).Conclusions:The mIL 2R level in PBMC HBeAg in serum of patients chronic hepatitis B were closely relatived with each other,lower in patients with chronic hepatitis than in normal controls.
出处
《蚌埠医学院学报》
CAS
1999年第2期79-81,共3页
Journal of Bengbu Medical College
