摘要
目的观察赤雹根的镇痛作用并筛选其有效部位。方法采用小鼠48℃热板法和扭体法,观察赤雹根水提物、醇提物及醇提物的石油醚萃取物、氯仿萃取物、正丁醇萃取物及水溶性部分的镇痛作用。结果除石油醚萃取物以外,其余赤雹根各提取物均能明显延长热板试验小鼠痛反应潜伏期,减少ip酒石酸锑钾所致小鼠扭体次数,上述作用的主要有效部位之一为正丁醇萃取物中所含的总皂苷。结论赤雹根具有明显的镇痛作用,其所含总皂苷为其镇痛作用的主要有效部位之一。
Objective To observe the analgesic effect and the effective fractions of the roots of Thladiantha dubia Bunge. Methods The analgesic effect of 2 extracts of the roots of Thladiantha dubia Bunge extracted by water and ethanol ,4 extracts of the ethanol extract by petroleumetter ,chloroform,N-butanol and water were respectively evaluated by the hot plate test （ 48℃） and classical writhing test in mice. Results Except the petroleumetter extract,the other extracts of the roots of Thladiantha dubia Bunge could markedly heighten the pain threshold value in 48℃hot-plate test and reduce the times of writhing induced by intraperitoneal injection of antimony potassium tartrate in mice. Total saponins was one of the most effective fractions of the N-butanol extract . Conclusion The roots of Thladiantha dubia Bunge has marked analgesic effect ,and total saponins is one of the most effective fractions.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2010年第10期2483-2484,共2页
Lishizhen Medicine and Materia Medica Research
基金
河北省自然科学基金(No.C2008000655)
关键词
赤雹
总皂苷
镇痛
Thladiantha dubia Bunge
Total saponins
Analgesic effect
