摘要
目的探讨肿瘤相关抗原CA125、TPS和血清铁蛋白含量联合检测对卵巢肿瘤的诊断意义。方法以我院2007年4月至2009年12月经超声诊断为卵巢肿瘤并行手术治疗患者328例为研究组。选择同期体检健康女性217例为对照组。比较分析2组血清CA125、TPS和铁蛋白含量及联合检测的敏感性、特异性、准确度、阳性预测值和阳性拟然比。结果卵巢恶性肿瘤患者血清CA125、TPS、铁蛋白含量显著高于卵巢良性肿瘤和正常对照人群(P<0.01);良性卵巢肿瘤患者血清CA125、TPS、铁蛋白含量亦高于正常对照组(P<0.01);以病理诊断为"金标准",血清CA125、TPS、铁蛋白含量联合检测对卵巢恶性肿瘤诊断的敏感性、特异性、准确度、阳性预测值和阳性拟然比均显著高于其3项单独检测指标(P<0.05,P<0.01)。结论 CA125、TPS、铁蛋白联合检测既可以作为诊断恶性卵巢肿瘤的可靠依据。
Objective To investigate the tumor-associated antigen CA125,TPS,and serum ferritin on the diagnosis of ovarian tumors.Methods 328 cases of ovarian tumors that treated by operation in April 2007 to December 2009 were as the study group;217 cases of healthy women by physical examination in the same period were as the control group.Comparative analysis the difference in levels of serum CA125,TPS,ferritin and the sensitivity,specificity,accuracy,positive predictive value,positive likelihood ratio by Individual or Joint test in two groups.Results The levels of serum CA125,TPS,ferritin in ovarian cancer was significantly higher than that in benign ovarian tumors and normal control group（P0.01）;the sensitivity,specificity,accuracy,positive predictive value,positive likelihood ratio by Joint test were significantly higher than those by Individual test（P0.05,P0.01）.Conclusion Joint test of CA125,TPS and ferritin can be used as a reliable evidence on diagnosis of ovarian malignant tumors,and also can distinguish the nature of different ovarian tumors.
出处
《中外医疗》
2010年第29期16-16,18,共2页
China & Foreign Medical Treatment
