摘要
目的探讨慢性心力衰竭（CHF）患者血清中CA125浓度的改变与心力衰竭程度的关系和影响其浓度的相关因素，正确评价其临床意义。方法血清CA125测定：抽取2ml空腹时的静脉血，分离血清进行免疫放射分析法测定浓度。123例患者按照纽约心脏病学会心功能分级标准，分为Ⅱ、Ⅲ、Ⅳ级组。设对照组20例。按有无心源性胸水而分为有胸水组和无胸水组，并对治疗前后的CA125浓度作对比。结果CHF患者CA125血清浓度明显高于对照组（P〈0．01），而且浓度的升高与心力衰竭的程度呈正相关。心源性胸水患者明显高于无心源性胸水患者。治疗后CA125的血清浓度随心衰好转而显著下降。结论CHF患者的CA125水平与左室射血分数（LVEF）值呈负相关，与心衰程度呈正相关；有心源性胸水者的CA125水平明显高于无心源性胸水者；CHF治疗后CA125水平显著下降。
Objective To study the relationship between the serum level of CA125 of patients with chronic heart failure and the severity of heart failure, and factors influencing the level of CA125, so as to evaluate it, s clinical significance. Method The level of CA125 was detected by immuno-analysis method after taking 2 ml venous blood of subjects. One hundred twenty-three patients were divided into Ⅱ , Ⅲ and Ⅳ three groups based on standard New York Heart Association classification. Twenty patients were recruited as control group. The patients were subdivided into pleural fluid subgroup and non-pleural fluid subgroup based on the pre^nce of fluid in the intrapleural. The level of CA125 was compared before and after treatment. Results The level of CA125 in the patients with heart failure or pleural fluid was higher than those in the control or non-pleural fluid patients, and level of CA125 was associated with the severity of heart failure. The level of CA125 decreased obviously following the improvement of heart failure. Conclusions The level of CA125 in patients with heart failure was negatively correlated with the level of EF. The level of CA125 in the pleural fluid group was higher than that of non-pleural fluid group. The level of CA125 decreased dramatically after treatment.
出处
《中华急诊医学杂志》
CAS
CSCD
2007年第4期424-426,共3页
Chinese Journal of Emergency Medicine
