摘要
目的探讨雌激素对慢性内脏痛雌鼠痛反应的影响及其与脊髓NMDA受体的关系。方法在♀大鼠新生期给予数次结直肠扩张刺激,成年后分为高、低雌激素组,用腹外斜肌放电水平来评价成鼠内脏痛觉敏感性,用NMDA受体拮抗剂D(-)-2-amino-5-phosphonopentanoic acid(AP-5)鞘内给药比较两组大鼠脊髓NMDA受体的功能。结果 (1)模型鼠高雌激素组的内脏痛反应比低雌激素组的反应强。(2)AP-5鞘内给药对内脏痛反应的抑制作用在模型鼠两组中的差异无统计学意义。结论高雌激素可加重模型雌鼠的内脏痛反应,雌激素不能使模型雌鼠脊髓背角的NMDA受体功能上调。
Aim To investigate the effect of estrogen on the reaction of chronic visceral pain female rats and its relationship with spinal cord NMDA receptor.Methods The model of irritable bowel syndrome was established by colorectal distension（CRD） in neonatal rats.The sensitivity of visceral pain was evaluated by responses to CRD which were measured as electromyographic（EMG） recordings of the external oblique muscle of abdomen（EOMA）.The function of spinal cord NMDA receptor was compared between the high and low estrogen groups by D（-）-2-amino-5-phosphonopentanoic acid（AP-5） intrathecal administration.Results（1） The visceral pain reaction of high estrogen model rats was stronger than that of the low estrogen model rats.（2） Intrathecal administration of AP-5 attenuated visceral pain response,but no significant difference in inhibition degree was found between the two groups.Conclusion High estrogen can exacerbate the sensitivity of visceral pain female rats.Estradiol can＇t increase the function of spinal cord NMDA receptor in model female rats.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2010年第9期1189-1192,共4页
Chinese Pharmacological Bulletin
基金
福建省自然科学基金资助项目(NoC0610022,No2009J01153)
关键词
内脏痛
雌激素
肌电
NMDA受体
大鼠
脊髓
visceral pain
estrogen
electromyographic
NMDA receptor
rat
spinal cord
