摘要
目的制备用于肝动脉栓塞的可显影碘化油-氟尿嘧啶(iodized oil-5-fluorouracil,iodized oil-5-Fu)聚乳酸(polylactide acid,PLA)微球。方法选择具有良好生物相容性及生物可降解性的聚乳酸为载体,加入阳性造影剂碘化油,采用复乳法制备可显影碘化油-氟尿嘧啶聚乳酸微球。以外观、粒径、载药量、包封率为考察指标,采用正交设计确定可显影碘化油-氟尿嘧啶聚乳酸微球的制备工艺。结果显微镜下微球球形圆整,粒径分布均匀,扫描电镜下微球表面有孔,平均粒径约100μm;载药量(10.78%±0.14%),包封率(63.34%±0.545%),微球显影效果好。结论以可生物降解的PLA材料可制备显影效果好的氟尿嘧啶微球,并且微球具有一定的缓释作用。
Objective To prepare visualized iodized oil-5-fluorouracil loaded polylactic acid（PLA）micropheres for hepatic artery embolism treatment.Methods Biocompatible and biodegradable material PLA was used as vector and iodized oil was used as positive contrast agent to prepare 5-fluorouracil loaded microspheres using double emulsion method.The preparation technology of the microspheres was developed through optimization of appearance,size distribution,drug loading, and encapsulation efficiency by orthogonal-designing method.Results The prepared PLA microspheres were round in shape and had a homogenous diameter distribution.Scanning electron microscope（SEM）showed a pored surface,with an average diameter of 100μm.The encapsulation efficiency and drug content of microspheres were（63.34%±0.54%）and（10.78%±0. 14%）,respectively.Conclusion We have successfully prepared the visualized iodized oil-5-fluorouracil PLA microspheres, which can release 5-fluorouracil in a controlled manner.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2010年第10期1100-1103,共4页
Academic Journal of Second Military Medical University
关键词
氟尿嘧啶
聚乳酸
碘化油
微球体
复乳法
fluorouracil
polylactie acid
iodized oil
microspheres
double emulsion method
