摘要
报道了丝裂霉素明胶微球（ＭＭＣ－ＧＭＳ）的研制方法，采用正交设计，优化了制备条件和工艺，采用动态透析法研究了微球的体外释药规律。结果表明：该微球粒径为５０～２００μｍ范围内的占微球总数的９０．２％；平均粒径为（６０．７６±９．６）μｍ，丝裂霉素的包封率为６８．４％，载药量为２０．８μｇ／ｍｇＧＭ．释药特性符合Ｈｉｇｕｃｈｉ方程。实验动物灌注微球后病理检查结果表明，灌注后微球成簇堵塞于肝动脉分枝的小动脉，其中大部分已完全堵塞了血管腔。
This paper introduced a method for preparing mitomycin-gelatin microspheres(MMC-GMS).Results:The diameters of 90.2% of the microspheres were between 50 to 200 μm,and the average diameter of the micropheres was(60 76±9 6)μm The drug content in every 1 mg microsphere was 20 8 μg The characteristic of drug release was accordance with Higuchi equation After hepatic artery infusion of the micropheres in experimental animals,the cavities of most of the small branches of the hepatic artery were totally obstructed.
出处
《广西医科大学学报》
CAS
1997年第3期49-51,共3页
Journal of Guangxi Medical University
关键词
肝动脉栓塞
丝裂霉素
明胶微球
肝肿瘤
hepatic artery transcather embolization
mitomycin
geltin microsphere
