摘要
背景与目的:人乳头状瘤病毒(human papilloma virus,HPV)作为食管癌发生重要的环境因素备受许多学者的关注,但其相关性未得到一致性公认,尤其对于高发的新疆哈萨克族食管癌。本研究探讨HPV16感染与新疆哈萨克族食管癌发生、发展的相关性。方法:采用半巢式聚合酶链反应(polymerase chain reaction,PCR)技术检测100例新疆哈萨克族食管癌患者癌组织和100例新疆哈萨克族正常人食管正常黏膜组织HPV16E6的感染情况。结果:新疆哈萨克族食管癌患者HPV16E6感染率为46%,明显高于新疆哈萨克族正常人群感染率的22%(P<0.001,OR=3.020);HPV16E6感染与新疆哈萨克族食管癌患者的发病年龄、性别、肿瘤生长部位、淋巴转移、分化程度无明显相关性(P均>0.05)。结论:HPV16E6感染与新疆哈萨克族食管癌发病密切相关,是其发病的重要因素之一。
Background and purpose：The human papilloma virus （HPV）,as an important environmental factor to esophageal carcinoma,has been studied by many scholars,but it has not been acknowledged consistently,especially among the high incidences of Kazakhstanian esophageal carcinoma cases in Xinjiang.The aim of this study was to investigate HPV16E6 infections in Kazakhstanian esophageal carcinoma.Methods：Using a polymerase chain reaction （PCR）,the HPV16 E6 gene infection was detected in 100 Kazakh patients with esophageal squamous carcinoma and in the mucosa of 100 normal Kazakh patients as control.Results：HPV16 E6 infection rate in Kazakh esophageal carcinoma was 46%,which was signifi cantly higher than that of the normal population infection rate （22%） （P0.001,OR=3.020）.There was no correlation between HPV16 E6 infection and age,gender,tumor site location,lymph node metastasis or the degree of differentiation among Kazakh patients （P0.05）.Conclusion：HPV16 E6 infection may be an important factor in causing squamous cell carcinoma among Kazakh patients.
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2010年第9期668-672,共5页
China Oncology
基金
国家“十一五”科技支撑计划(项目编号:2009BAI82B03)
