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阿司匹林抵抗的研究进展 被引量：4

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摘要 阿司匹林（Aspirin），别名乙酰水杨酸，由德国的化学家Hoffman于1897年首先合成，并于1899年作为抗炎、解热和镇痛药进入临床，商品名阿司匹林。1971年，Smith和Willis发现，阿司匹林可以抑制血小板前列腺素（prostaglandin，PG）的合成。阿司匹林的抗血小板聚集作用正是通过不可逆的抑制环氧合酶1（cyclooxygenase，COX-1），将花生四烯酸（arachidonic acid）生成血栓素（thromboxane）而实现的。
作者 王斌
机构地区 首都医科大学宣武医院神经外科
出处 《中国脑血管病杂志》 CAS 2010年第10期553-556,共4页 Chinese Journal of Cerebrovascular Diseases
关键词 阿司匹林 血小板聚集抑制剂 血栓烷类
分类号 R971 [医药卫生—药品]
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参考文献23

  • 1Juck DB.One hundred years of aspirin[J].Lancet,1997,350(9075):437-439.
  • 2Smilh JB,Willis AL.Aspirin selectively inhibits prostaglandin production in human platelets[J].Nat New Biol,1971,231(25):235-237.
  • 3Antithrombotic Trialists' Collaboration.Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death,myocardial infarction,and stroke in high risk patients[J].BMJ,2002,324(7329):71-86.
  • 4Mehta P.Aspirin in the prophylaxis of coronary artery disease[J].Curr Opin Cardioi,2002,17(5):552-558.
  • 5Grotemeyer KH,Scharafinski HW,Husstedt IW.Twoyear follow-up of aspirin responder and a.spirin non-responder:a pilot-study including 180 post stroke patients[J].Thromb Res,1993,71(5):397-403.
  • 6王林,刘道安,孙晓军.阿司匹林抵抗的争议[N].健康报,2007-10-22(4).
  • 7Hennekens CH,Schror K,Weisman S.et al.Terms and conditions:semantic complexity and aspirin resistance[J].Circulation,2004,110(12):1706-1708.
  • 8Davis JW,Hartman CR,Lewis HD Jr,et al.Cigarette smoking-induced enhancement of platelet function:lack of prevention by aspirin in men with coronary artery disease[J].J Lab Clin Med,1985,105(4):479-483.
  • 9Catella-Lawson F,Reilly MP,Kapoor SC,et al.Cyclooxygenase Inhibitors and the antiplatelet effects of aspirin[J].N Engl J Med,2001,345(25):1809-1817.
  • 10Tohgi H,Konno S,Tamura K,et al.Effects of low-tohigh doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclin[J].Stroke,1992,23(10):1400-1403.

同被引文献43

  • 1王倩,韩萍.阿司匹林对糖尿病患者心脑血管事件一级预防的荟萃分析[J].中华糖尿病杂志,2009,1(6). 被引量：3
  • 2陈忠龙,吴小南.肠粘膜屏障与胃肠疾病[J].海峡预防医学杂志,2007,13(2):31-33. 被引量：17
  • 3Levine G N, Bates E R, Blankenship J C, et al. 2011 AC- CF/AHA/SCAI Guideline for Percutaneous Coronary Inter- vention: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angi- ography and Interventions [ J ]. Circulation, 2011, 124 (23) : e574-651.
  • 4Mehta S R, Tanguay J F, Eikelboom J W, et al. Double- dose versus standard-dose clopidogrel and high-dose versuslow-dose aspirin in individuals undergoing percutaneous cor- onary intervention for acute coronary syndromes (CUR- RENT-OASIS 7 ) : a randomised factorial trial[ J ]. Lancet, 2010,376 ( 9748 ) : 1233- 1243.
  • 5Schomig A, Neumann F J, Kastrati A, et al. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents [ J ]. N Engl J Med, 1996,334(17) :1084- 1089.
  • 6Collaborative meta-analysis of randomised trials of antiplate- let therapy for prevention of death, myocardial infarction, and stroke in high risk patients [ J ]. BMJ, 2002, 324 (7329) :71-86.
  • 7Baigent C, Blackwell L, Collins R, et al. Aspirin in the primary and secondary prevention of vascular disease: col- laborative meta-analysis of individual participant data from randomised trials [ J ]. Lancet, 2009, 373 ( 9678 ) : 1849- 1860.
  • 8Wiviott S D, Braunwald E, McCabe C H, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes [J3. N Engl J Med, 2007,357(20) :2001-2015.
  • 9Wallentin L, Becker R C, Budaj A, et al. Ticagrelor ver- sus clopidogrel in patients with acute coronary syndromes [J]. N Engl J Med, 2009,361(11) :1045-1057.
  • 10Held C, Asenblad N, Bassand J P, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes under- going coronary artery bypass surgery: results from the PLA- TO(Platelet Inhibition and Patient Outcomes) trial [ J ]. J Am Coil Cardiol, 2011,57 (6) :672-684.

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中国脑血管病杂志
2010年 第10期

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