摘要
近十年来,血栓素(thromboxane)被认为在烧伤后真皮进行性缺血过程中起重要作用,有报导前列腺素、血栓素抑制剂可改善局部血循环,从而促进深Ⅱ度烧伤刨而愈合。本实验以啄鼠深Ⅱ度烧伤模型,肌注血栓素合成酶抑制剂Dazmegrel(UK38,485或uk)3.4mg/kg/天(UK3.4mg)、10mE/kg/天(UK10mg)、或30mg/kg/天(UK30mg),使用印度墨汁灌注及UK-133(氙-133)清除试验,未发现Dazfilegrel能改善烧伤局部血流。这与有的实验结论不同,肌注Dazmegrel 3.4rag/kg/天的促进烧伤创面愈合作用,不是由于该药改善局部血流量所致。此外,Xe-133清除试验示伤后7小时深Ⅱ度烧伤皮肤血流量有一明显下降过程,伤后24小时则有一明显增加过程,如何认识及应用这一"先低后高。现象,对促进深Ⅱ度烧伤创面愈合显然是有意义的。
We have previously demonstrated more rapid wound healing in deep partial thickness burn guinea-pigs treated with intramuscular injection of the lower dosage of the thromboxane synthetase inhibitor Dazmegrel. In striking contrast, systemical and topical application of larger dosage of Dazmegrel inhibited or did not improve wound healingi in this study, a deep partial thickness burn model of guinea-pig was used to evaluate the effect of Dazmegrel given systemically using dosage of 3.4mg, 10mg and 30mg/kg/day on dermal perfusion measured by India ink injction or by Xe-133 clearance. There was no improvement of dermal perfusion in any of the groups receiving Dazmegrel. The beneficial effect of Dazmegrel on wound healing at a dosage of 3.4mg/kg/day was not due to improved local dermal perfusion but, rather, resulted from a systemic immune effect on the animal The Xe-133-determined blood perfusion showed a significantly diminished blood perfusion in the burn wound at 7h post-burn, and a higher burn skin blood flow at 24h post-burn. Their finding is consistent with the report from other laboratory that microvascularr perfusion in zone-of-stasis burns, immediately post-burn, gradually diminishes to nil over the next 16 hours, to be followed by reperfusion between 16 and 96 hours postbturn.
