摘要
采用滴制法制备了布洛芬滴丸剂 ,筛选了滴丸剂的处方和工艺 ,并考察其体外溶出度。结果表明以崩解剂羧甲基淀粉钠作为基质 (用量为 2 0 % )的布洛芬滴丸溶出速度最快 ,10 min溶出就达 99.4% ,大大高于市售布洛芬片的 38.9% (P<0 .0 1)
Eight formulations of ibuprofen pills were developed with sodium carboxy methylstarch, sodium carboxymethylcellulose, L hydroxypropylcellulose, tween 80, aerosil, PEG 1500 and PEG 6000, using melt drop method. The dissolution profile of the ibuprofen pills in vitro was investigated. The results showed that the ibuprofen pills containing 20% sodium carboxymethylstarch had the highest dissolution rate. The cumulative dissolution percentage in 10 min was 99.4%, which was two times higher than that of the reference tablets ( P <0.01).\;
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2000年第9期399-402,共4页
Chinese Journal of Pharmaceuticals
