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来氟米特联合中小剂量泼尼松治疗老年慢性肾小球肾炎的疗效观察 被引量:35

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摘要 目的观察新型免疫抑制剂来氟米特联合中小剂量泼尼松治疗老年慢性肾小球肾炎的疗效和安全性。方法选择符合条件的慢性肾小球肾炎患者48例,随机分为2组,试验组口服来氟米特及中小剂量泼尼松治疗,对照组口服血管紧张转换酶抑制剂(贝那普利)和双嘧达莫等常规治疗,总疗程6个月。观察治疗前后24h尿蛋白定量、肝肾功能、血尿常规、血浆白蛋白及不良反应等情况。结果试验组治疗后24h尿蛋白定量较治疗前明显减少(P<0.01),与对照组比较有显著性差异(P<0.05);试验组完全缓解率68%,总有效率为82%,与对照组比较有显著性差异(P<0.05);不同肾组织病理类型与疗效比较试验组系膜增生性肾小球肾炎的疗效优于其他病理类型。结论来氟米特联合中小剂量泼尼松治疗老年慢性肾小球肾炎较常规治疗起效快、疗效好,且副作用较少。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2010年第18期2576-2578,共3页 Chinese Journal of Gerontology
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