摘要
用电镜方法观察了超剂量ＲＵ４８６对大鼠肾上腺和甲状腺细胞超微结构的影响。实验大鼠给药７ｄ、１４ｄ、２８ｄ，每天３０ｍｇ／ｍｌ／只。结果：肾上腺皮质束状带细胞溶酶体增多增大，胞质内和细胞间出现髓样小体，巨噬细胞胞质中形成巨大残余样结构，其超微结构改变随用药时间延长加重。球状带、网状带、髓质细胞以及甲状腺滤泡上皮细胞、滤泡旁细胞超微结构与对照组无显著差别。提示超剂量ＲＵ４８６对大鼠肾上腺皮质束状带细胞有一定损害，但对肾上腺其它部位及甲状腺影响不明显。
Ultrastructures of adrenal gland and thyroid gland cells was observed after administeration of overdosage of mifepristone (RU486) with TEM in rats. RU486 was administered intragastrically to rats of three experimental groups at a dose of 30mg/ml once a day for 7,14 and 28 days respectively. The results were as follows: the lysosomes in the fascicular zone cells of adrenal cortex increased in size; the myelin bodies were presented in cytoplasm and intercellular space; a number of large remnant bodylike structures were formed in the macrophages; these pathological alterations were exacerbated with prolongation of the administrational period, the glomerular zone, reticular zone, adrenal medulla cells and follicular epthelial cells, parafollicular cells either in experiment groups or control groups kept no any alterations. The results indicate that overdosage of mifepristone can damage the facicular zone cells in a certain degree and has no significant effect on cells of other parts of adrenal gland and thyroid gland.
出处
《解剖科学进展》
CAS
1999年第2期163-165,共3页
Progress of Anatomical Sciences
