摘要
目的:测定国产甲磺酸左氧氟沙星注射液在人体的药物动力学.方法:12名健康受试者恒速iv gtt 200mg/0.5h,用HPLC法测定血清中和尿液中甲磺酸左氧氟沙星浓度.结果:经药物动力学计算程序拟合,符合二室模型.其初始血药浓度C_0为(3.54±0.24)mg/L,T_(1/2β)为(6.53±0.96)h,CL为(14.063±2.639)L/h,V/F为(38.529±3.913)L,AUC为(14.63±2.41)[(mg/L)·h].24h内累积尿药排泄率为(62.97±5.86)%.各项药物动力学参数与国外文献报道基本相符.结论:甲磺酸左氧氟沙星国产与进口产品的体内处置过程相同.
AIM: To study the disposition of levofloxacin (LVFX). METHODS: Twelve healthy volunteers were infused with 200 mg LVFX. Serum concentration of LVFX was determined by HPLC. RESULTS:Diposed by 3P87 program,its pharmacokinetics parameters were calculated by two compartment model in all subjects:c0= (3. 54 ± 0. 24) mg/L,T_(1/2β) = (6. 53 ± 0. 96)h,CL=(14. 063 ± 2. 639)L/h,V/F = (38. 529 ± 3. 913)L,AUC = (14. 63 ± 2.41)[(mg/L) · h]. These parameters were similar to those reported in foreign journals. CONCLUSION: The results indicate that there are no significant differences between domes-tic and foreign formulations.
出处
《中国临床药学杂志》
CAS
1999年第3期161-164,共4页
Chinese Journal of Clinical Pharmacy
关键词
甲磺酸
左氧氟沙星
药物动力学
HPLC
levofloxacin
pharmacokinetics
high performance liguid chromatography
