摘要
左旋氧氟沙星和氧氟沙星是氟喹诺酮类抗菌药，前者是旋光性Ｓ－（一）的氧氟沙星异构体。左旋氧氟沙星在体外的抗菌活性一般是氧氟沙星的两倍。两药对大多数需氧性革兰氏阳性菌和革兰氏阴性菌都有效，对多种感染有效，具有抗菌谱广、抗菌活性强并有良好的体液、组织分布性。其不良反应轻、细菌耐药性小等优点。左旋氧氟沙星由于构形的改变，在与氧氟沙星对比的试验中，左旋氧氟沙星按氧氟沙星一半的每日剂量，治疗下呼吸道感染和有并发症的尿路感染等，证明其效力相等而不良反应发生率较低。服氧氟沙星和左旋氧氟沙星时不用调整茶碱的剂量；与抗酸剂或其它含二价、三价阳离子的药物同服，会减少左旋氧氟沙星和氧氟沙星的吸收。
Levofloxacin and ofloxacin were two new oral fluoroquinolones. But the former was the optical s-(-) isomer of ofloxacin. The in vitro antimicrobial activity of levofloxacin was two folder higher than that of ofloxacin. The two drugs were active against most aerobic gram-negative and gram-positive organism and were effective against most infections. Levofloxacin had characterization of broad spectrum, high antimicrobial activity, favourable body fluid and tissue disturbation property, mild adverse drug reaction and few resistance. Because of the modification of its structure, levefloxacin had been proved the same effective and few adverse drug reaction compared with ofloxaction in randomizated controlled clinical trails of lower respiratory tract infection and urinary tract infections with complication when levofloxacin and ofloxacin were administrated simultaneously, but the absorption of levofloxacin and ofloxacin would be decreased when they were administrated with antiacid agents for other divalent, trivalent cation drugs simultaneously.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1997年第2期115-119,共5页
The Chinese Journal of Clinical Pharmacology
