摘要
目的:观察左旋氧氟沙星(LVFX)在胆道手术后患者的胆药浓度及其影响因素。方法:13例施行胆道手术并行T-管引流的患者poLVFX200mg,q8h,连服5d,用HPLC法测定LVFX在血浆、胆汁中的药物浓度。结果:胆囊结石降低胆汁中药物浓度;胆道梗阻程度与胆汁药物浓度有密切相关性,梗阻程度愈高,药物浓度愈低。结论:胆道疾病(特别是结石性胆道疾病)所造成的胆道梗阻状态在很大程度上影响LVFX在胆道的浓度,梗阻状态下低胆汁药物浓度将不利于感染的治疗。
AIM:To study the concentration of levofloxacin(LVFX)in bile. METHODS: Thirteen patients undering biliary tract operations with T-tube drainages were given LVFX 200 mg,q8h for 5 d. Plasma and bile samples were measured by high performance liquid chro-matography. RESULTS:The cholecystolithiasis reduced the concentration of LVFX in gall-bladder bile. The relationship between the concentration of LVFX in bile and the status of biliary tract obstruct was confirmed. The more serious obstruct the patients were ,the lower biliary concentration of LVFX they will be. CONCLUSION:Cholelithiasis and bile tract ob-struct will effect LVFX penetration into biliary tract obviously. Under these condition the low concentration of LVFX in bile will be unfavourable to infectious treatment.
出处
《中国临床药学杂志》
CAS
1999年第3期140-142,共3页
Chinese Journal of Clinical Pharmacy
