摘要
目的：探讨５—Ｆｕ门静脉灌注辅助化疗在防治大肠癌根治术后肝转移的临床使用价值；方法：随机对照的大肠癌患者７７例，其中根治术加门静脉灌注化疗３７例，单纯根治术４０例。每年进行随访；结果：门静脉灌注辅助化疗方便、安全，不增加手术并发症。术后近期随访显示，肝转移发生，化疗组术后１年内２例（２／３７），以后均未发现；对照组１年内２例（２／４０）、２年内１例（１／２６）、３年内１例（１／１３）。统计学处理，ｘ２检验Ｐ＞０．０５，两组发生率无差异；结论：５—Ｆｕ门静脉灌注化疗能减少部分大肠癌根治术后患者的肝转移，同时建议增加辅助化疗疗程或同时进行其它有效的综合治疗。
Objective:To investigate the effect on the provention and cure of liver metastases by the chemotherapy of port vein infussion (PVI)after radical surgerry for large bowl cancer.Methods:Among the 77 patients randomly assined and compared with 37 patients recived 5 Fu based chemotherapy by PVI,the others had no further treatment.all patient were followed.Results:The chemotherapy by PVI.It′s convenience and safety It did not increase the rate of complication.1 cases of 37 patients who recieved PVI were discovered had liver matastases in the first year.none of them were discoverd in the followed years.1 cases of 40 patients in the first year and 1 of 26 patients in the seconed year;1 of 13 Patients in the third year were discovered respectively in the group who had no further treatment.The estimate satistically was no significant (x 2 test P>0.05).Conclusion:PVI of 5 Fu after surgery in some the of patients with large bowl cancer may reduced the rate of liver matastases and the author suggested that prolonge the course of PVI and undertook other effective remedy may be benefit.
出处
《河北医学》
CAS
1999年第6期16-18,共3页
Hebei Medicine
关键词
大肠癌
药物疗法
肝转移癌
门静脉辅助化疗
Large bowl cancer
Chemotherapy
Liver matastasses
Port vein infussion(PVI)
