摘要
以水杨酸和乙酸酐为原料,磷钨酸为催化剂催化合成乙酰水杨酸。考察了催化剂用量、反应物料配比、反应时间、温度等因素对反应的影响。结果表明,最佳工艺条件为：水杨酸∶乙酸酐∶磷钨酸的物质的量比为1∶2.5∶0.002 4,反应时间25 min,反应温度76~80℃。该法具有反应条件温和、催化剂用量小、酐醇比小、无污染、后处理简单等优点。
Synthesis of acetyl salicylic acid from salicylic acid and acetic anhydride using phosphotungstic acid as catalyst,the optimum conditions for the reaction were as follows：The amount of substance ratio of salicylic acid,anthydride acetic and phosphotungstic acid is 1∶2.5∶0.002 4,the reaction time is 25 min,the reaction temperature is 76~80 ℃,the method has many advantages：mild operation condition,low catalyst dosage,no pollution and easy treatment.
出处
《应用化工》
CAS
CSCD
2010年第9期1373-1375,共3页
Applied Chemical Industry
关键词
乙酰水杨酸
磷钨酸
催化合成
acetyl salicylic acid
phosphotungstic acid
catalytic synthesis
